Cue-induced craving among inhalant users: Development and preliminary validation of a visual cue paradigm

被引:1
作者
Jain, Shobhit [1 ]
Dhawan, Anju [2 ]
Kumaran, S. Senthil [3 ]
Pattanayak, Raman Deep [4 ]
Jain, Raka [2 ,5 ]
机构
[1] Banaras Hindu Univ BHU, Inst Med Sci IMS, Dept Psychiat, Varanasi 221005, Uttar Pradesh, India
[2] All India Inst Med Sci AIIMS, Dept Psychiat, Natl Drug Dependence Treatment Ctr NDDTC, New Delhi 110029, India
[3] All India Inst Med Sci AIIMS, Dept NMR & MRI Facil, New Delhi, India
[4] All India Inst Med Sci AIIMS, Dept Psychiat, New Delhi, India
[5] All India Inst Med Sci AIIMS, Natl Drug Dependence Treatment Ctr NDDTC, New Delhi, India
关键词
Cue induced craving; Inhalant abuse; Visual cues; Validation; Adolescents; Volatile solvents; INDUCED BRAIN ACTIVATION; ALCOHOL; REACTIVITY; SPECIFICITY; STRIATUM;
D O I
10.1016/j.ajp.2017.10.004
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Introduction: Cue-induced craving is known to be associated with a higher risk of relapse, wherein drug-specific cues become conditioned stimuli, eliciting conditioned responses. Cue-reactivity paradigm are important tools to study psychological responses and functional neuroimaging changes. However, till date, there has been no specific study or a validated paradigm for inhalant cue-induced craving research. The study aimed to develop and validate visual cue stimulus for inhalant cue-associated craving. Method: The first step (picture selection) involved screening and careful selection of 30 cue-and 30 neutral-pictures based on their relevance for naturalistic settings. In the second step (time optimization), a random selection of ten cue-pictures each was presented for 4 s, 6 s, and 8 s to seven adolescent male inhalant users, and pre-post craving response was compared using a Visual Analogue Scale(VAS) for each of the picture and time. In the third step (validation), craving response for each of 30 cue- and 30 neutral-pictures were analysed among 20 adolescent inhalant users. Results: Findings revealed a significant difference in before and after craving response for the cue-pictures, but not neutral-pictures. Using ROC-curve, pictures were arranged in order of craving intensity. Finally, 20 best cueand 20 neutral-pictures were used for the development of a 480 s visual cue paradigm. Conclusion: This is the first study to systematically develop an inhalant cue picture paradigm which can be used as a tool to examine cue induced craving in neurobiological studies. Further research, including its further validation in larger study and diverse samples, is required.
引用
收藏
页码:202 / 207
页数:6
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