Retinal oximetry in glaucoma: investigations and findings reviewed

被引：18

作者：

Shughoury, Aumer ^{[1
]}

Mathew, Sunu ^{[1
]}

Arciero, Julia ^{[2
]}

Wurster, Patrick ^{[1
]}

Adjei, Susuana ^{[1
]}

Ciulla, Thomas ^{[3
]}

Siesky, Brent ^{[4
]}

Harris, Alon ^{[4
]}

机构：

[1] Indiana Univ Sch Med, Eugene & Marilyn Glick Eye Inst, Dept Ophthalmol, Indianapolis, IN 46202 USA

[2] Indiana Univ Purdue Univ, Dept Math Sci, Indianapolis, IN 46202 USA

[3] Midwest Eye Inst, Indianapolis, IN USA

[4] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

来源：

ACTA OPHTHALMOLOGICA | 2020年 / 98卷 / 06期

基金：

美国国家科学基金会;

关键词：

mathematical modelling; normal tension glaucoma; ocular blood flow; primary open-angle glaucoma; retinal oximetry; retinal oxygen demand; OPEN-ANGLE GLAUCOMA; OCULAR BLOOD-FLOW; VESSEL OXYGEN-SATURATION; VISUAL-FIELD LOSS; OPTIC-NERVE HEAD; SIMULATED CATARACT; PERFUSION-PRESSURE; HEALTHY; TENSION; METABOLISM;

D O I：

10.1111/aos.14397

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Abnormalities of the retinal blood supply have been widely implicated in primary open-angle glaucoma (POAG). Impaired blood supply to the retina and optic nerve head (ONH) may be a primary pathophysiologic mechanism contributing to POAG ('vascular hypothesis'). However, the decreased metabolic activity of atrophic tissue is itself known to induce both vascular changes and decreased blood flow due to reduced oxygen demand. Therefore, primary nonvascular factors could potentially induce glaucomatous atrophy, with subsequent secondary vascular pathology ('mechanical hypothesis'). Retinal oximetry holds great promise in the investigation of glaucoma pathogenesis, as it can provide useful data on retinal metabolic oxygen demand, especially when combined with measurements of retinal blood flow. This review surveys the research on retinal metabolism in POAG using spectroscopic retinal oximetry. The use of mathematical models in combination with oximetric data to investigate the role of retinal metabolism and oxygen supply in POAG is also discussed.

引用

页码：559 / 571

页数：13