Non-Directed Cross-Dehydrogenative (Hetero) arylation of Allylic C(sp3)-H bonds enabled by C-H Activation

被引：62

作者：

Lerchen, Andreas ^{[1
]}

Knecht, Tobias ^{[1
]}

Koy, Maximilian ^{[1
]}

Ernst, Johannes B. ^{[1
]}

Bergander, Klaus ^{[1
]}

Daniliuc, Constantin G. ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 46期

关键词：

allylic arylation; cross-dehydrogenative coupling; heteroarenes; rhodium; TERMINAL ALKENES; CARBOXYLIC-ACIDS; ALKYLATION; OXIDATION; AMINATION; FUNCTIONALIZATION; CATALYST; OLEFINS; SULFONAMIDES; SELECTIVITY;

D O I：

10.1002/anie.201807047

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report the selective, non-directed and cross- dehydrogenative coupling of allylic C(sp(3))-H bonds with C(sp(2))-H bonds of (hetero) arenes. The methodology employs olefins and (hetero) arenes which are abundantly available chemical feedstocks, and could be applied in late-stage functionalization reactions of pharmaceuticals. Furthermore, the system exclusively delivers the allylic C-C coupling products highlighting the preservation of the olefin substitution pattern for further derivatization.

引用

页码：15248 / 15252

页数：5

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