Comprehensive Molecular Profiling of FLT3-Mutated Acute Myeloid Leukemia (AML) Patients Treated within the Ratify Trial (Alliance C10603)

被引:0
作者
Jahn, Nikolaus [1 ]
Panina, Ekaterina [1 ]
Bullinger, Lars [2 ]
Dolnik, Anna [2 ]
Herzig, Julia [1 ]
Blaette, Tamara J. [2 ]
Benner, Axel [3 ]
Krzykalla, Julia [3 ]
Gathmann, Insa [4 ]
Larson, Richard A. [5 ,6 ]
Lo-Coco, Francesco [7 ]
Amadori, Sergio [7 ]
Prior, Thomas W. [8 ]
Brandwein, Joseph M. [9 ]
Appelbaum, Frederick R. [10 ]
Medeiros, Bruno C. [11 ]
Tallman, Martin S. [12 ]
Tiecke, Eva [13 ]
Pallaud, Celine [14 ]
Ehninger, Gerhard [15 ]
Heuser, Michael [16 ]
Ganser, Arnold [16 ]
Stone, Richard M. [17 ]
Thiede, Christian [15 ]
Doehner, Hartmut [1 ]
Bloomfield, Clara D. [8 ]
Doehner, Konstanze [1 ]
机构
[1] Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany
[2] Charite, Dept Hematol Oncol & Tumorimmunol, Berlin, Germany
[3] German Canc Res Ctr, Div Biostat, Heidelberg, Germany
[4] Novartis Pharma AG, Basel, Switzerland
[5] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA
[6] Univ Chicago, Ctr Comprehens Canc, Chicago, IL 60637 USA
[7] Univ Roma Tor Vergata, Rome, Italy
[8] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[9] Princess Margaret Hosp, Dept Med Oncol & Hematol, Toronto, ON, Canada
[10] Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA
[11] Stanford Univ, Ctr Canc, Stanford, CA 94305 USA
[12] Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA
[13] Novartis Pharmaceut, Basel, Switzerland
[14] Novartis Pharmaceut, Oncol Precis Med, Novartis Oncol BU, Basel, Switzerland
[15] Univ Hosp Carl Gustav Carus, Internal Med 1, Dresden, Germany
[16] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany
[17] Dana Farber Partners CancerCare, Dept Med Oncol, Boston, MA USA
关键词
D O I
10.1182/blood-2018-99-115842
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1534
引用
收藏
页数:6
相关论文
共 50 条
[41]   Follow-up of Patients With FLT3-Mutated Relapsed or Refractory Acute Myeloid Leukaemia in the Phase 3 ADMIRAL Trial [J].
Perl, Alexander E. ;
Larson, Richard A. ;
Podoltsev, Nikolai A. ;
Strickland, Stephen ;
Wang, Eunice S. ;
Atallah, Ehab ;
Schiller, Gary J. ;
Martinelli, Giovanni ;
Neubauer, Andreas ;
Sierra, Jorge ;
Montesinos, Pau ;
Recher, Christian ;
Yoon, Sung-Soo ;
Hosono, Naoko ;
Onozawa, Masahiro ;
Chiba, Shigeru ;
Kim, Hee-Je ;
Hasabou, Nahla ;
Lu, Qiaoyang ;
Tiu, Ramon ;
Levis, Mark J. .
BRITISH JOURNAL OF HAEMATOLOGY, 2022, 197 :6-7
[42]   Outcomes with Sequential FLT3-Inhibitor (FLT3i) Based Therapies in Patients (pts) with FLT3-Mutated Acute Myeloid Leukemia (AML) Exposed to Prior FLT3i Based Therapies [J].
Yilmaz, Musa ;
Alfayez, Mansour ;
Kadia, Tapan M. ;
DiNardo, Courtney D. ;
Borthakur, Gautam ;
Loghavi, Sanam ;
Konopleva, Marina ;
Kanagal-Shamanna, Rashmi ;
Patel, Keyur ;
Jabbour, Elias ;
Garcia-Manero, Guillermo ;
Pemmaraju, Naveen ;
Pierce, Sherry A. ;
Issa, Ghayas C. ;
Short, Nicholas J. ;
Bravo, Guillermo Montalban ;
Takahashi, Koichi ;
Assi, Rita ;
Alotaibi, Ahmad S. ;
Andreeff, Michael ;
Cortes, Jorge E. ;
Kantarjian, Hagop M. ;
Ravandi, Farhad ;
Daver, Naval .
BLOOD, 2020, 136
[43]   Venetoclax Plus Hypomethylating Agent (HMA) Based Induction for Treatment-Naive Older/Unfit Patients with FLT3-Mutated Acute Myeloid Leukemia (AML) [J].
Ghorab, Ahmad ;
Litzow, Mark R. ;
Gangat, Naseema ;
Al-Kali, Aref ;
Shah, Mithun, V ;
Murthy, Hemant S. ;
Tefferi, Ayalew ;
Alkhateeb, Hassan B. ;
Begna, Kebede ;
Patnaik, Mrinal M. ;
Foran, James M. ;
Badar, Talha .
BLOOD, 2022, 140 :9019-9020
[44]   Gilteritinib significantly prolongs overall survival in patients with FLT3-mutated relapsed/refractory acute myeloid leukemia: results from the phase 3 ADMIRAL trial [J].
Perl, A. E. ;
Martinelli, G. ;
Cortes, J. E. ;
Neubauer, A. ;
Berman, E. ;
Paolini, S. ;
Montesinos, P. ;
Baer, M. R. ;
Larson, R. A. ;
Ustun, C. ;
Fabbiano, F. ;
Di Stasi, A. ;
Stuart, R. ;
Olin, R. ;
Kasner, M. ;
Ciceri, F. ;
Chou, W. -C. ;
Podoltsev, N. ;
Recher, C. ;
Yokoyama, H. ;
Hosono, N. ;
Yoon, S. -S. ;
Lee, J. -H. ;
Pardee, T. ;
Fathi, A. T. ;
Liu, C. ;
Liu, X. ;
Bahceci, E. ;
Levis, M. J. .
ONCOLOGY RESEARCH AND TREATMENT, 2019, 42 :295-295
[45]   Emerging Mutations at Relapse in Patients with FLT3-Mutated Relapsed/Refractory Acute Myeloid Leukemia Who Received Gilteritinib Therapy in the Phase 3 Admiral Trial [J].
Smith, Catherine C. ;
Levis, Mark J. ;
Perl, Alexander E. ;
Martinelli, Giovanni ;
Neubauer, Andreas ;
Berman, Ellin ;
Montesinos, Pau ;
Baer, Maria R. ;
Larson, Richard A. ;
Chou, Wen-Chien ;
Yokoyama, Hisayuki ;
Recher, Christian ;
Yoon, Sung-Soo ;
Hill, Jason E. ;
Rosales, Matt ;
Bahceci, Erkut .
BLOOD, 2019, 134
[46]   CLONAL EVOLUTION OF FLT3-ITD POSITIVE AML AT DIAGNOSIS AND RELAPSE IN PATIENTS TREATED WITHIN THE CALGB 10603 (RATIFY) AND AMLSG 16-10 TRIALS [J].
Schmalbrock, L. K. ;
Cocciardi, S. ;
Dolnik, A. ;
Agrawal, M. ;
Theis, F. ;
Jahn, N. ;
Blaette, T. J. ;
Gaidzik, V. I. ;
Paschka, P. ;
Fiedler, W. ;
Salih, H. ;
Wulf, G. ;
Germing, U. ;
Luebbert, M. ;
Thol, F. ;
Heuser, M. ;
Larson, R. A. ;
Ganser, A. ;
Schlenk, R. F. ;
Stone, R. M. ;
Doehner, H. ;
Doehner, K. ;
Bullinger, L. .
HAEMATOLOGICA, 2017, 102 :358-358
[47]   Treatment With FLT3 Inhibitor in Patients With FLT3-Mutated Acute Myeloid Leukemia Is Associated With Development of Secondary FLT3-Tyrosine Kinase Domain Mutations [J].
Alvarado, Yesid ;
Kantarjian, Hagop M. ;
Luthra, Rajyalakshmi ;
Ravandi, Farhad ;
Borthakur, Gautam ;
Garcia-Manero, Guillermo ;
Konopleva, Marina ;
Estrov, Zeev ;
Andreeff, Michael ;
Cortes, Jorge E. .
CANCER, 2014, 120 (14) :2142-2149
[48]   GILTERITINIB SIGNIFICANTLY PROLONGS OVERALL SURVIVAL IN PATIENTS WITH FLT3-MUTATED RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA: RESULTS FROM THE PHASE 3 ADMIRAL TRIAL [J].
Perl, A. E. ;
Martinelli, G. ;
Cortes, J. E. ;
Neubauer, A. ;
Berman, E. ;
Paolini, S. ;
Montesinos, P. ;
Baer, M. R. ;
Larson, R. A. ;
Ustun, C. ;
Fabbiano, F. ;
Di Stasi, A. ;
Stuart, R. ;
Olin, R. ;
Kasner, M. ;
Ciceri, F. ;
Chou, W. ;
Podoltsev, N. ;
Recher, C. ;
Yokoyama, H. ;
Hosono, N. ;
Yoon, S. ;
Pardee, J. Lee T. ;
Fathi, A. T. ;
Liu, C. ;
Liu, X. ;
Bahceci, E. ;
Levis, M. J. .
HAEMATOLOGICA, 2019, 104 :2-2
[49]   Azacitidine and Venetoclax Followed By Sequential Gilteritinib Is an Effective Alternative in Very Frail Patients with FLT3-Mutated Acute Myeloid Leukemia [J].
Nedumannil, Rithin ;
Matley, Chelsea ;
Bajel, Ashish ;
Levis, Mark J. ;
Wei, Andrew H. .
BLOOD, 2024, 144 :6060-6061
[50]   Posaconazole and midostaurin in patients with FLT3-mutated acute myeloid leukemia: Pharmacokinetic interactions and clinical facts in a real life study [J].
Menna, Pierantonio ;
Marchesi, Francesco ;
Cattaneo, Chiara ;
Candoni, Anna ;
Delia, Mario ;
Nadali, Gianpaolo ;
Vatteroni, Alessandra ;
Pasciolla, Crescenza ;
Perrone, Salvatore ;
Verga, Luisa ;
Armiento, Daniele ;
Del Principe, Maria Ilaria ;
Fracchiolla, Nicola S. S. ;
Salvatorelli, Emanuela ;
Lupisella, Santina ;
Terrenato, Irene ;
Busca, Alessandro ;
Minotti, Giorgio ;
Pagano, Livio .
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2023, 16 (10) :1876-1885