Extracellular Hydrolysis of Adenine Nucleotides and Nucleoside Adenosine is Higher in Patients with ST Elevation than Non-ST Elevation in Acute Myocardial Infarction

被引：4

作者：

Lavall, Marines Calegari ^{[1
]}

Bagatini, Margarete Dulce ^{[2
]}

Thome, Gustavo Roberto ^{[1
]}

Bonfanti, Gabriela ^{[3
]}

Moretto, Maria Beatriz ^{[3
]}

de Oliveira, Liliane Zimmermann ^{[4
]}

Brucker, Natalia ^{[3
]}

Morsch, Vera Maria ^{[1
]}

Chitolina Schetinger, Maria Rosa ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Programa Posgrad Ciencias Biol Bioquim Toxicol, Ctr Ciencias Nat & Exatas, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Fed Fronteira Sul, Curso Enfermagem, Chapeco, SC, Brazil

[3] Univ Fed Santa Maria, Dept Anal Clin & Toxicol, Ctr Ciencias Saude, BR-97105900 Santa Maria, RS, Brazil

[4] HUSM, Serv Hematol & Oncol, Lab Imunofenotipagem, Santa Maria, RS, Brazil

来源：

CLINICAL LABORATORY | 2015年 / 61卷 / 07期

关键词：

acute myocardial infarction; platelets; adenine nucleotides; nucleoside adenosine; TISSUE-FACTOR; IN-VIVO; CORONARY; ACCUMULATION; DEFINITION; ACTIVATION; THROMBOSIS; DEAMINASE; REGISTRY;

D O I：

10.7754/Clin.Lab.2014.141136

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The hydrolysis of adenine nucleotide linked to the membrane of the platelets is changed in acute myocardial infarction (AMI) probably due to a greater arterial blockage and cell damage in patients with ST elevation (STEM!) than in those without ST segment elevation (NSTEMI). Methods: This study aimed to compare the extracellular hydrolysis of adenine nucleotides on the platelet surface of STEM! and NSTEMI patients. This study was carried out with 50 patients with AMI (STEMI and NSTEMI). The extracellular hydrolysis of adenine nucleotides and nucleoside adenosine as well as the expression of NTPDase were verified in platelets. Results: The results demonstrated that STEMI patients had significantly higher extracellular hydrolysis of adenine nucleotides (p < 0.001), ADA (adenosine deaminase) activity (p < 0.05), as well as troponin levels (p < 0.0001) when compared to NSTEMI patients. Conclusions: Findings suggest that the extracellular hydrolysis of adenine nucleotides and increase in the ADA activity are higher in patients with STEMI than in those with NSTEMI probably because there was a blockage in this major arterial with a large area of damaged tissue.

引用

页码：761 / 767

页数：7

共 29 条

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