Serological response to trivalent inactive influenza vaccine in HIV-infected children with different immunologic status

被引：12

作者：

Kosalaraksa, Pope ^{[1
]}

Srirompotong, Ussanee ^{[1
]}

Newman, Robert W.

Lumbiganon, Pagakrong ^{[1
]}

Wood, John M.

机构：

[1] Khon Kaen Univ, Fac Med, Dept Pediat, Khon Kaen, Thailand

来源：

VACCINE | 2011年 / 29卷 / 16期

关键词：

HIV; Children; Influenza vaccine; Serological response; ACTIVE ANTIRETROVIRAL THERAPY; IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL-ACTIVATION; ANTIBODY-RESPONSE; HIV-1-INFECTED PATIENTS; VIRAL REPLICATION; IMMUNE-RESPONSE; DOUBLE-BLIND; RNA LEVELS; IMMUNIZATION;

D O I：

10.1016/j.vaccine.2011.01.091

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Influenza vaccination is usually recommended for HIV-infected children. One hundred and twenty seven HIV-infected and twenty-one HIV-uninfected children aged >= 6 months to <18 years, all of whom were naive to influenza vaccine, were enrolled to receive an influenza Trivalent Inactivated Vaccine (TIV). In the HIV group, the post-vaccination immune response (geometric mean titer, seroconversion and seroprotection rates) correlated with their immunological status before vaccination. The HIV-infected children with no immunosuppression had comparable serological response to HIV-uninfected children. For moderately and severely immunosuppressed HIV groups, two doses of TIV resulted in greater serological responses and should be recommended in these groups. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3055 / 3060

页数：6

共 40 条

[1] Persistent humoral immune defect in highly active antiretroviral therapy-treated children with HIV-1 infection: Loss of specific antibodies against attenuated vaccine strains and natural viral infection [J].