Novel Chiral Skeletons for Drug Discovery: Antibacterial Tetramic Acids

被引：26

作者：

Holloway, Chloe A. ^{[1
]}

Matthews, Christopher J. ^{[1
]}

Jeong, Yong-Chul ^{[1
]}

Moloney, Mark G. ^{[1
]}

Roberts, Christine F. ^{[1
]}

Yaqoob, Muhammad ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2011年 / 78卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

drug design; molecular diversity; natural product; NATURAL-PRODUCTS; INHIBITORS; MOLECULES; CHEMISTRY; DESIGN; POTENT;

D O I：

10.1111/j.1747-0285.2011.01133.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modification of the ring nucleus of tetramic acids derived from serine gives chiral heterocyclic libraries that exhibit antibacterial activity, and correlation with various physicochemical parameters indicates that chiral tetramic acids may provide a potentially valuable non-aromatic skeleton for fragment-based drug discovery.

引用

页码：229 / 235

页数：7

共 51 条

[1] Andrews MD, 1996, SYNLETT, P612
[2] Regioselective Dieckmann cyclisations leading to enantiopure highly functionalised tetramic acid derivatives
Andrews, MD
Brewster, AG
Crapnell, KM
Ibbett, AJ
Jones, T
Moloney, MG
Prout, K
Watkin, D
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (02): : 223 - 235
[3] A CONCISE APPROACH TO FUNCTIONALIZED, HOMOCHIRAL TETRAMIC ACIDS
ANDREWS, MD
BREWSTER, A
MOLONEY, MG
[J]. TETRAHEDRON-ASYMMETRY, 1994, 5 (08) : 1477 - 1478
[4] Efficient enantioselective synthesis of tetramic acids and lactams from threonine
Anwar, Muhammad
Moloney, Mark G.
[J]. TETRAHEDRON LETTERS, 2007, 48 (41) : 7259 - 7262
[5] Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity
Anwar, Muhammad
Cowley, Andrew R.
Moloney, Mark G.
[J]. TETRAHEDRON-ASYMMETRY, 2010, 21 (13-14) : 1758 - 1770
[6] On the antibiotic activity of oxazolomycin
Bagwell, Claire L.
Moloney, Mark G.
Thompson, Amber L.
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (14) : 4081 - 4086
[7] Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation
Bagwell, Claire L.
Moloney, Mark G.
Yaqoob, Muhammad
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (07) : 2090 - 2094
[8] Breinbauer R, 2002, ANGEW CHEM INT EDIT, V41, P2879
[9] Discovery and optimization of antibacterial AccC inhibitors
Cheng, Cliff C.
Shipps, Gerald W., Jr.
Yang, Zhiwei
Sun, Binyuan
Kawahata, Noriyuki
Soucy, Kyle A.
Soriano, Aileen
Orth, Peter
Xiao, Li
Mann, Paul
Black, Todd
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (23) : 6507 - 6514
[10] A rule of three for fragment-based lead discovery?
Congreve, M
Carr, R
Murray, C
Jhoti, H
[J]. DRUG DISCOVERY TODAY, 2003, 8 (19) : 876 - 877

← 1 2 3 4 5 6 →