Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

被引：6

作者：

Anisimova, Natalia ^{[1
,2
]}

Martynenko, Natalia ^{[3
]}

Novruzov, Keryam ^{[1
]}

Rybalchenko, Olga ^{[3
]}

Kiselevskiy, Mikhail ^{[1
,2
]}

Rybalchenko, Georgy ^{[4
]}

Straumal, Boris ^{[2
,5
,6
,7
]}

Salishchev, Gennady ^{[8
]}

Mansharipova, Almagul ^{[9
]}

Kabiyeva, Aigul ^{[10
]}

Gabdullin, Maratbek ^{[11
]}

Dobatkin, Sergey ^{[2
,3
]}

Estrin, Yuri ^{[12
,13
]}

机构：

[1] Minist Hlth Russian Federat NN Blokhin NMRCO, NN Blokhin Natl Med Res Ctr Oncol, Moscow 115478, Russia

[2] Natl Univ Sci & Technol MISIS, Dept Phys Met & Phys Strength, Lab Funct Polymer Mat, Moscow 119991, Russia

[3] RAS, AA Baikov Inst Met & Mat Sci, Moscow 119334, Russia

[4] RAS, PN Lebedev Phys Inst, Moscow 142432, Russia

[5] Karlsruhe Inst Technol, Inst Nanotechnol, D-76344 Eggenstein Leopoldshafen, Germany

[6] Russian Acad Sci, Inst Solid State Phys, Chernogolovka 142432, Russia

[7] Russian Acad Sci, Chernogolovka Sci Ctr, Chernogolovka 142432, Russia

[8] Belgorod Natl Res Univ, Lab Bulk Nanostruct Mat, Belgorod 308015, Russia

[9] Kazakh Russian Med Univ, Dept Sci & Clin Work, Alma Ata 050000, Kazakhstan

[10] Assoc Early Career Doctors Almaty, Alma Ata 050000, Kazakhstan

[11] Kazakh British Tech Univ, Alma Ata 050000, Kazakhstan

[12] Monash Univ, Dept Mat Sci & Engn, Clayton, Vic 3800, Australia

[13] Univ Western Australia, Dept Mech Engn, Perth, WA 6009, Australia

来源：

METALS | 2022年 / 12卷 / 01期

关键词：

magnesium alloy; multiaxial deformation; biodegradation; cell viability; cell colonization; BONE; CORROSION; IMPLANTS; CEMENTS;

D O I：

10.3390/met12010105

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The study shows that multiaxial deformation (MAD) treatment leads to grain refinement in magnesium alloy WE43. Compared to the initial state, the MAD-processed alloy exhibited smoother biocorrosion dynamics in a fetal bovine serum and in a complete cell growth medium. Examination by microCT demonstrated retardation of the decline in the alloy volume and the Hounsfield unit values. An attendant reduction in the rate of accumulation of the biodegradation products in the immersion medium, a less pronounced alkalization, and inhibited sedimentation of biodegradation products on the surface of the alloy were observed after MAD. These effects were accompanied with an increase in the osteogenic mesenchymal stromal cell viability on the alloy surface and in a medium containing their extracts. It is expected that the more orderly dynamics of biodegradation of the WE43 alloy after MAD and the stimulation of cell colonization will effectively promote stable osteosynthesis, making repeat implant extraction surgeries unnecessary.

引用

页数：16

共 38 条

[1] Use of Resorbable Implants for Mandibular Fixation A Systematic Review [J].

Agarwal, Shailesh ;

Gupta, Anish ;

Grevious, Mark ;

Reid, Russell R. .

JOURNAL OF CRANIOFACIAL SURGERY, 2009, 20 (02) :331-339

[2] A comprehensive review on biocompatible Mg-based alloys as temporary orthopaedic implants: Current status, challenges, and future prospects [J].

Bairagi, Darothi ;

Mandal, Sumantra .

JOURNAL OF MAGNESIUM AND ALLOYS, 2022, 10 (03) :627-669

[3]

Bamford C.H., 1992, VROMAN EFFECT

[4] Calcium Phosphate Bone Cements [J].

Barinov, S. M. ;

Komlev, V. S. .

INORGANIC MATERIALS, 2011, 47 (13) :1470-1485

[5]

Bohner M, 2010, EUR CELLS MATER, V20, P1

[6]

Cooper S.L., 1982, Biomaterials: Interfacial Phenomena and Applications

[7] Mechanical Properties, Biodegradation, and Biocompatibility of Ultrafine Grained Magnesium Alloy WE43 [J].

Dobatkin, Sergey ;

Martynenko, Natalia ;

Anisimova, Natalia ;

Kiselevskiy, Mikhail ;

Prosvirnin, Dmitriy ;

Terentiev, Vladimir ;

Yurchenko, Nikita ;

Salishchev, Gennady ;

Estrin, Yuri .

MATERIALS, 2019, 12 (21)

[8] Fundamentals and advances in magnesium alloy corrosion [J].

Esmaily, M. ;

Svensson, J. E. ;

Fajardo, S. ;

Birbilis, N. ;

Frankel, G. S. ;

Virtanen, S. ;

Arrabal, R. ;

Thomas, S. ;

Johansson, L. G. .

PROGRESS IN MATERIALS SCIENCE, 2017, 89 :92-193

[9] Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes [J].

Ewald, Andrea ;

Kreczy, Dorothea ;

Brueckner, Theresa ;

Gbureck, Uwe ;

Bengel, Melanie ;

Hoess, Andreas ;

Nies, Berthold ;

Bator, Julia ;

Klammert, Uwe ;

Fuchs, Andreas .

MATERIALS, 2019, 12 (13)

[10] Antibacterial and cell-friendly copper-substituted tricalcium phosphate ceramics for biomedical implant applications [J].

Fadeeva, Inna, V ;

Lazoryak, Bogdan, I ;

Davidova, Galina A. ;

Murzakhanov, Fadis F. ;

Gabbasov, Bulat F. ;

Petrakova, Natalya, V ;

Fosca, Marco ;

Barinov, Sergey M. ;

Vadala, Gianluca ;

Uskokovic, Vuk ;

Zheng, Yufeng ;

Rau, Julietta, V .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2021, 129

← 1 2 3 4 →