Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

被引：180

作者：

Margiana, Ria ^{[1
,2
,3
]}

Markov, Alexander ^{[4
,5
]}

Zekiy, Angelina O. ^{[6
]}

Hamza, Mohammed Ubaid ^{[7
]}

Al-Dabbagh, Khalid A. ^{[8
]}

Al-Zubaidi, Sura Hasan ^{[9
]}

Hameed, Noora M. ^{[10
]}

Ahmad, Irshad ^{[11
]}

Sivaraman, R. ^{[12
]}

Kzar, Hamzah H. ^{[13
]}

Al-Gazally, Moaed E. ^{[14
]}

Mustafa, Yasser Fakri ^{[15
]}

Siahmansouri, Homayoon ^{[16
]}

机构：

[1] Univ Indonesia, Dept Anat, Fac Med, Jakarta, Indonesia

[2] Univ Indonesia, Masters Programme Biomed Sci, Fac Med, Jakarta, Indonesia

[3] Dr Soetomo Gen Acad Hosp, Surabaya, Indonesia

[4] Tyumen State Med Univ, Tyumen, Russia

[5] Tyumen Ind Univ, Tyumen, Russia

[6] IM Sechenov First Moscow State Med Univ, Dept Prosthet Dent, Sechenov Univ, Moscow, Russia

[7] Al Farahidi Univ, Med Tech Coll, Baghdad, Iraq

[8] Al Hadba Univ Coll, Dept Dent, Mosul, Iraq

[9] Al Mustaqbal Univ Coll, Anesthesia Tech Dept, Babylon, Iraq

[10] Al Nisour Univ Coll, Anesthesia Tech, Baghdad, Iraq

[11] King Khalid Univ, Dept Med Rehabil Sci, Coll Appl Med Sci, Abha, Saudi Arabia

[12] Univ Madras, Dept Math, Dwaraka Doss Goverdhan Doss Vaishnav Coll, Chennai, Tamil Nadu, India

[13] Al Qasim Green Univ, Vet Med Coll, Al Qasim, Iraq

[14] Univ Al Ameed, Coll Med, Karbala, Iraq

[15] Univ Mosul, Dept Pharmaceut Chem, Coll Pharm, Mosul 41001, Iraq

[16] Tabriz Univ Med Sci, Dept Immunol, Fac Med, Tabriz, Iran

来源：

STEM CELL RESEARCH & THERAPY | 2022年 / 13卷 / 01期

关键词：

Mesenchymal stromal cell; Regenerative medicine; Stem cell therapy; Tissue regeneration; Cell therapy; AMYOTROPHIC-LATERAL-SCLEROSIS; SPINAL-CORD-INJURY; RANDOMIZED CONTROLLED-TRIAL; PLATELET-RICH PLASMA; REGULATORY T-CELLS; STROMAL CELLS; INTRAVENOUS-INFUSION; PHASE; 1/2; IN-VITRO; TRANSPLANTATION;

D O I：

10.1186/s13287-022-03054-0

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MSCs can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and hide themselves from the immune system. Certainly, various investigations have revealed anti-inflammatory, anti-aging, reconstruction, and wound healing potentials of MSCs in many in vitro and in vivo models. Moreover, current progresses in the field of MSCs biology have facilitated the progress of particular guidelines and quality control approaches, which eventually lead to clinical application of MSCs. In this literature, we provided a brief overview of immunoregulatory characteristics and immunosuppressive activities of MSCs. In addition, we discussed the enhancement, utilization, and therapeutic responses of MSCs in neural, liver, kidney, bone, heart diseases, and wound healing.

引用

页数：22

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