Effects of estrogen on learning-memory and expression of calbindin-D28K in hippocampus in vascular dementia rats

被引：0

作者：

Li, Jing ^{[2
]}

Zhang, Lei ^{[1
]}

Li, Jiao-Jiao ^{[1
]}

Xian-Qu ^{[1
]}

Chen, Lin ^{[3
]}

Li, Dong-Ying ^{[4
]}

Li, Chun-Ying ^{[1
]}

机构：

[1] Beihua Univ, Basic Med Coll, Dept Physiol, Jilin, Jilin, Peoples R China

[2] Beihua Univ, Nursing Coll, Jilin, Jilin, Peoples R China

[3] Beihua Univ, Affiliated Hosp, Jilin, Jilin, Peoples R China

[4] Sixth Peoples Hosp Jilin City, Jilin, Jilin, Peoples R China

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2017年 / 30卷 / 04期

关键词：

Vascular dementia; Learning-memory; Hippocampus; Calbindin-D28K; CALCIUM; NEURONS; RECEPTOR;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vascular dementia (VD) models were made first by repeating cerebral ischemia-reperfusion and followed by treating with estrogen. Learning-memory ability was measured by Morris water maze. Concentration of Ca2+ in hippocampus was determined by Fura-2/AM fluorescence probe and the expression of Calbindin-D28K (CB) in hippocampal CA1 was tested by immunohistochemistry. Learning-memory ability, was improved in E group, rats; Concentration of Ca2+ in hippocampus was decreased in E group rats. The expression of CB was less in E group rats. It implies that estrogen could improve learning-memory ability in VD rats, which may be associated with suppressing intracellular Ca2+ overload and increasing the expression of CB in hippocampus.

引用

页码：1403 / 1406

页数：4

共 16 条

[1]

Allahtavakoli M, 2015, BASIC CLIN NEUROSCI, V6, P185

[2] CALCIUM-BINDING PROTEINS IN THE NERVOUS-SYSTEM [J].

BAIMBRIDGE, KG ;

CELIO, MR ;

ROGERS, JH .

TRENDS IN NEUROSCIENCES, 1992, 15 (08) :303-308

[3] Using the Morris Water Maze to Assess Spatial Learning and Memory in Weanling Mice [J].

Barnhart, Christopher D. ;

Yang, Dongren ;

Lein, Pamela J. .

PLOS ONE, 2015, 10 (04)

[4] CALCIUM BUFFERING PROPERTIES OF CALBINDIN-D(28K) AND PARVALBUMIN IN RAT SENSORY NEURONS [J].

CHARD, PS ;

BLEAKMAN, D ;

CHRISTAKOS, S ;

FULLMER, CS ;

MILLER, RJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1993, 472 :341-357

[5]

CHOI DW, 1994, ANN NY ACAD SCI, V747, P162

[6] Prevalence of neuropsychiatric symptoms in elderly patients with dementia in Mungialde County (Basque country, Spain) [J].

Fernandez Martinez, Manuel ;

Castro Flores, Jessica ;

Perez de las Heras, Susana ;

Mandaluniz Lekumberri, Aitxiber ;

Gordejuela Menocal, Maria ;

Zarranz Imirizaldu, Juan Jose .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2008, 25 (02) :103-108

[7]

Ge Chao-Liang, 2015, Chin J Nat Med, V13, P823, DOI 10.1016/S1875-5364(15)30086-8

[8] CALCIUM SIGNALING IN NEURONS - MOLECULAR MECHANISMS AND CELLULAR CONSEQUENCES [J].

GHOSH, A ;

GREENBERG, ME .

SCIENCE, 1995, 268 (5208) :239-247

[9]

Hyrc K, 1997, J NEUROSCI, V17, P6669

[10] Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats [J].

Li, Hui ;

Liu, Yi ;

Lin, Li-Ting ;

Wang, Xue-Rui ;

Du, Si-Qi ;

Yan, Chao-Qun ;

He, Tian ;

Yang, Jing-Wen ;

Liu, Cun-Zhi .

NEUROCHEMISTRY INTERNATIONAL, 2016, 92 :35-42

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