MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients

被引：73
作者：
Langers, A. M. J. [1 ]
Verspaget, H. W. [1 ]
Hawinkels, L. J. A. C. [1 ,2 ]
Kubben, F. J. G. M. [1 ]
van Duijn, W. [1 ]
van der Reijden, J. J. [1 ]
Hardwick, J. C. H. [1 ]
Hommes, D. W. [1 ]
Sier, C. F. M. [1 ,3 ]
机构：
[1] Leiden Univ Med Ctr, Dept Gastroenterol Hepatol, NL-2300 RC Leiden, Netherlands
[2] Leiden Univ Med Ctr, Dept Mol Cell Biol, NL-2300 RC Leiden, Netherlands
[3] Leiden Univ Med Ctr, Dept Surg, NL-2300 RC Leiden, Netherlands
来源：
BRITISH JOURNAL OF CANCER | 2012年 / 106卷 / 09期
关键词：
matrix metalloproteinase; normal mucosa; carcinoma; SNP; survival; angiogenesis; ELISA; PLASMINOGEN ACTIVATORS; ANGIOGENESIS; ADJACENT; GENE; EXPRESSION; INHIBITORS; PHENOTYPE; SURVIVAL; TISSUE; COLON;
D O I：
10.1038/bjc.2012.80
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS: A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (-1306C>T) and MMP-9 (-1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification. CONCLUSION: MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients. British Journal of Cancer (2012) 106, 1495-1498. doi:10.1038/bjc.2012.80 www.bjcancer.com Published online 3 April 2012 (C) 2012 Cancer Research UK
引用
收藏
页码：1495 / 1498
页数：4
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