A portrait of Transforming Growth Factor β superfamily signalling: Background matters

被引：179
作者：
Horbelt, Daniel [1 ]
Denkis, Agnieszka [1 ,2 ]
Knaus, Petra [1 ,2 ]
机构：
[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
[2] Berlin Brandenburg Sch Regenerat Therapies BSRT, Berlin, Germany
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 03期
关键词：
TGF-beta; BMP; SMAD; Non-SMAD; BODY MORPHOGENETIC PROTEINS; TGF-BETA; SMAD1/5; PHOSPHORYLATION; MESENCHYMAL TRANSITION; BMP RECEPTOR; BONE; COMPLEXES; PATHWAYS; BINDING; CANCER;
D O I：
10.1016/j.biocel.2011.12.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ligands of the Transforming Growth Factor beta superfamily like Transforming Growth Factor beta and Bone Morphogenetic Proteins govern developmental processes and regulate adult homeostasis by controlling cellular proliferation, survival, differentiation and migration. Aberrant signalling activity is associated with human disorders such as cancer, cardiovascular, musculoskeletal, or fibrotic disease. Upon binding to specific sets of cognate cell surface receptors, family members induce highly similar pathways which include canonical SMAD dependent signalling as well as pathways without direct involvement of SMAD proteins, which activate signalling molecules like mitogen-activated protein kinases or small GTPases. The diverse ligand functionalities are achieved through regulation and modulation of the pathways at all levels, resulting in a highly quantitative and context sensitive signal integration reflecting the cellular state and background. Strategies to target Transforming Growth Factor beta or Bone Morphogenetic Protein pathways have been developed on the basis of our current understanding and have proven a highly beneficial potential. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：469 / 474
页数：6
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