Convenient Synthesis of Nε-(Carboxymethyl)lysine, a Key Advanced Glycation Endproduct Biomarker

被引：6

作者：

Andersen, Jeanette M. ^{[1
]}

Hjelmgaard, Thomas ^{[1
]}

Dragsted, Lars O. ^{[2
]}

Nielsen, John ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Basic Sci & Environm, DK-1871 Frederiksberg C, Denmark

[2] Univ Copenhagen, Dept Human Nutr, DK-1958 Frederiksberg C, Denmark

来源：

SYNLETT | 2012年 / 04期

关键词：

CML; AGE biomarker; amino acids; amination; natural products; CACO-2 CELL MONOLAYERS; MAILLARD REACTION; END-PRODUCTS; TRANSEPITHELIAL FLUX; AMINO-ACID; CARBOXYMETHYLLYSINE; IDENTIFICATION; TRANSPORT; PEPTIDES; PROTEINS;

D O I：

10.1055/s-0031-1290348

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N-epsilon-(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.

引用

页码：531 / 534

页数：4

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