Malignant schwannoma of the sciatic nerve originating in a spinal plexiform neurofibroma associated with neurofibromatosis type 1 - Case report

被引：20

作者：

Topsakal, C

Akdemir, I

Tiftikci, M

Ozercan, I

Aydin, Y

机构：

[1] Firat Univ, Sch Med, Dept Neurosurg, Elazig, Turkey

[2] Firat Univ, Sch Med, Dept Pathol, Elazig, Turkey

[3] Sisli Etfal Hosp, Dept Neurosurg, Istanbul, Turkey

来源：

NEUROLOGIA MEDICO-CHIRURGICA | 2001年 / 41卷 / 11期

关键词：

neurilemmoma; neurofibroma; malignant peripheral nerve sheath tumor; malignant schwannoma; von Recklinghausen's disease;

D O I：

10.2176/nmc.41.551

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 26-year-old man with neurofibromatosis type 1 (NF1) presented with a giant malignant schwannoma of the sciatic nerve. The differential diagnosis of malignant peripheral nerve sheath tumor (MPNST) was based on clinical, radiological, and histological evidence. The tumor apparently originated in a spinal plexiform neurofibroma. The lesion was resected totally without neural damage to the sciatic nerve. However, the tumor recurred within 2 months. The patient died of unknown factors probably associated with the spinal involvement. MPNST associated with NF1 has a poor prognosis due to recurrence or metastasis despite complete macroscopic removal.

引用

页码：551 / 555

页数：5

共 46 条

[31]

RUSSELL DS, 1977, PATHOL TUMOURS NER, P26

[32] GENETIC-LINKAGE OF VONRECKLINGHAUSEN NEUROFIBROMATOSIS TO THE NERVE GROWTH-FACTOR RECEPTOR GENE [J].

SEIZINGER, BR ;

ROULEAU, GA ;

OZELIUS, LJ ;

LANE, AH ;

FARYNIARZ, AG ;

CHAO, MV ;

HUSON, S ;

KORF, BR ;

PARRY, DM ;

PERICAKVANCE, MA ;

COLLINS, FS ;

HOBBS, WJ ;

FALCONE, BG ;

IANNAZZI, JA ;

ROY, JC ;

STGEORGEHYSLOP, PH ;

TANZI, RE ;

BOTHWELL, MA ;

UPADHYAYA, M ;

HARPER, P ;

GOLDSTEIN, AE ;

HOOVER, DL ;

BADER, JL ;

SPENCE, MA ;

MULVIHILL, JJ ;

AYLSWORTH, AS ;

VANCE, JM ;

ROSSENWASSER, GOD ;

GASKELL, PC ;

ROSES, AD ;

MARTUZA, RL ;

BREAKEFIELD, XO ;

GUSELLA, JF .

CELL, 1987, 49 (05) :589-594

[33] SPINAL MALIGNANT NERVE-SHEATH TUMOR OR CELLULAR SCHWANNOMA - A STRIKING DIFFERENCE IN PROGNOSIS [J].

SEPPALA, MT ;

HALTIA, MJJ .

JOURNAL OF NEUROSURGERY, 1993, 79 (04) :528-532

[34] SEGMENTAL NEUROFIBROMATOSIS OF THE SCIATIC-NERVE - CASE-REPORT [J].

SIEB, JP ;

SCHULTHEISS, R .

NEUROSURGERY, 1992, 31 (06) :1122-1125

[35]

SORDILLO PP, 1981, CANCER-AM CANCER SOC, V47, P2503, DOI 10.1002/1097-0142(19810515)47:10<2503::AID-CNCR2820471033>3.0.CO

[36]

2-3

[37]

STAY EJ, 1977, CANCER, V39, P2550, DOI 10.1002/1097-0142(197706)39:6<2550::AID-CNCR2820390636>3.0.CO

[38]

2-Y

[39]

STEFANSSON K, 1982, AM J PATHOL, V106, P261

[40]

Stout AP, 1935, AM J CANCER, V25, P1

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