Non-canonical Notch signaling: emerging role and mechanism

被引：179

作者：

Andersen, Peter ^{[1
]}

Uosaki, Hideki ^{[1
]}

Shenje, Lincoln T. ^{[1
]}

Kwon, Chulan ^{[1
]}

机构：

[1] Johns Hopkins Univ, Div Cardiol, Dept Med, Baltimore, MD 21205 USA

来源：

TRENDS IN CELL BIOLOGY | 2012年 / 22卷 / 05期

关键词：

NEURAL CREST FORMATION; BETA-CATENIN; INTRACELLULAR DOMAIN; CELL FATE; TUMOR-SUPPRESSOR; GAMMA-SECRETASE; DROSOPHILA-NOTCH; SULINDAC SULFIDE; PATHWAY; PROTEIN;

D O I：

10.1016/j.tcb.2012.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although the 'canonical' Notch pathway and its core members are well established involving ligand-induced cleavage of Notch for transcriptional regulation - it has been unclear whether Notch can also function independently of ligand and transcription ('non-canonically') through a common mechanism. Recent studies suggest that Notch can non-canonically exert its biological functions by post-translationally targeting Wnt/beta-catenin signaling, an important cellular and developmental regulator. The non-canonical Notch pathway appears to be highly conserved from flies to mammals. Here, we discuss the emerging conserved mechanism and role of ligand/transcription-independent Notch signaling in cell and developmental biology.

引用

页码：257 / 265

页数：9

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