Gliotoxin Analogues from a Marine-Derived Fungus, Penicillium sp., and Their Cytotoxic and Histone Methyltransferase Inhibitory Activities

被引：94

作者：

Sun, Yi ^{[1
]}

Takada, Kentaro ^{[1
]}

Takemoto, Yasushi ^{[2
]}

Yoshida, Minoru ^{[2
]}

Nogi, Yuichi ^{[3
]}

Okada, Shigeru ^{[1
]}

Matsunaga, Shigeki ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Lab Aquat Nat Prod Chem, Bunkyo Ku, Tokyo 1138657, Japan

[2] RIKEN, Adv Sci Inst, Chem Genom Res Grp, Wako, Saitama 3510198, Japan

[3] Japan Agcy Marine Earth Sci & Technol JAMSTEC, Yokosuka, Kanagawa 2370061, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 01期

关键词：

BIOSYNTHESIS; METABOLITES;

D O I：

10.1021/np200740e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven gliotoxin-related compounds were isolated from the fungus Penicillium sp. strain JMF034, obtained from deep sea sediments of Suruga Bay, Japan. These included two new metabolites, bis(dethio)-10a-methylthio-3a-deoxy-3,3a-didehydrogliotoxin (1) and 6-deoxy-5a,6-didehydrogliotoxin (2), and five known metabolites (3-7). The structures of the new compounds were elucidated by analysis of spectroscopic data and the application of the modified Mosher's analysis. All of the compounds exhibited cytotoxic activity, whereas compounds containing a disulfide bond showed potent inhibitory activity against histone methyltransferase (HMT) G9a. None of them inhibited HMT SET7/9.

引用

页码：111 / 114

页数：4

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