Alzheimer's disease risk factor complement receptor 1 is associated with depression

被引：17
作者：
Hamilton, Gillian [1 ,2 ]
Evans, Kathryn L. [1 ,2 ]
MacIntyre, Donald J. [1 ]
Deary, Ian J. [2 ]
Dominiczak, Anna [3 ]
Smith, Blair H.
Morris, Andrew D. [4 ]
Porteous, David J. [1 ,2 ]
Thomson, Pippa A. [1 ,2 ]
机构：
[1] Univ Edinburgh, Mol Med Ctr, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
[2] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Dept Psychol, Edinburgh, Midlothian, Scotland
[3] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland
[4] Univ Dundee, Med Res Inst, Clin Res Ctr, Dundee DD1 4HN, Scotland
来源：
NEUROSCIENCE LETTERS | 2012年 / 510卷 / 01期
基金：
英国医学研究理事会; 英国经济与社会研究理事会; 英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词：
Association study; Major recurrent depression; Complement receptor 1; Alzheimer's disease; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; CLU; DISORDER; PICALM; SCALE; CR-1;
D O I：
10.1016/j.neulet.2011.12.059
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Variation in the complement receptor 1 gene (CR1) has been identified in recent genome-wide association studies as a risk factor for Alzheimer's disease. Here, we show that two Alzheimer's disease-associated CR1 variants, rs6656401 and rs3818361, are associated with major recurrent depression in females in a population-based cohort using individuals from the Generation Scotland: Scottish Family Health Study. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：6 / 9
页数：4
相关论文
共 27 条
  • [1] [Anonymous], MOL PSYCHIAT
  • [2] [Anonymous], 1977, Manual for raven's progressive matrices and vocabulary scales
  • [3] [Anonymous], 2002, STRUCTURED CLIN INTE
  • [4] [Anonymous], 2008, R: A language and environment for statistical computing
  • [5] [Anonymous], 1932, Archives of Psychology, DOI DOI 10.4135/9781412961288.N454
  • [6] CR1 Is Associated with Amyloid Plaque Burden and Age-Related Cognitive Decline
    Chibnik, Lori B.
    Shulman, Joshua M.
    Leurgans, Sue E.
    Schneider, Julie A.
    Wilson, Robert S.
    Tran, Dong
    Aubin, Cristin
    Buchman, Aron S.
    Heward, Christopher B.
    Myers, Amanda J.
    Hardy, John A.
    Huentelman, Matthew J.
    Corneveaux, Jason J.
    Reiman, Eric M.
    Evans, Denis A.
    Bennett, David A.
    De Jager, Philip L.
    [J]. ANNALS OF NEUROLOGY, 2011, 69 (03) : 560 - 569
  • [7] Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals
    Corneveaux, Jason J.
    Myers, Amanda J.
    Allen, April N.
    Pruzin, Jeremy J.
    Ramirez, Manuel
    Engel, Anzhelika
    Nalls, Michael A.
    Chen, Kewei
    Lee, Wendy
    Chewning, Kendria
    Villa, Stephen E.
    Meechoovet, Hunsar B.
    Gerber, Jill D.
    Frost, Danielle
    Benson, Hollie L.
    O'Reilly, Sean
    Chibnik, Lori B.
    Shulman, Joshua M.
    Singleton, Andrew B.
    Craig, David W.
    Van Keuren-Jensen, Kendall R.
    Dunckley, Travis
    Bennett, David A.
    De Jager, Philip L.
    Heward, Christopher
    Hardy, John
    Reiman, Eric M.
    Huentelman, Matthew J.
    [J]. HUMAN MOLECULAR GENETICS, 2010, 19 (16) : 3295 - 3301
  • [8] A REVISED VERSION OF THE PSYCHOTICISM SCALE
    EYSENCK, SBG
    EYSENCK, HJ
    BARRETT, P
    [J]. PERSONALITY AND INDIVIDUAL DIFFERENCES, 1985, 6 (01) : 21 - 29
  • [9] Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment
    Fernandez, Manuel
    Gobartt, Ana L.
    Balana, Montse
    [J]. BMC NEUROLOGY, 2010, 10
  • [10] Goldberg D., 1978, GEN HLTH QUESTIONNAI
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