Prognostic variables in high-risk cutaneous squamous cell carcinoma: a review

被引：31

作者：

Cheng, Judy ^{[1
]}

Yan, Shaofeng ^{[2
]}

机构：

[1] Geisel Sch Med Dartmouth, Hanover, NH USA

[2] Dartmouth Hitchcock Med Ctr, Dept Pathol, Lebanon, NH 03756 USA

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2016年 / 43卷 / 11期

关键词：

cutaneous squamous cell carcinoma; prognosis; staging; management; AMERICAN JOINT COMMITTEE; LYMPH-NODE METASTASES; PERINEURAL INVASION; STAGING SYSTEM; MATRIX METALLOPROTEINASES; ADENOSQUAMOUS CARCINOMA; BASOSQUAMOUS CARCINOMA; ADJUVANT RADIOTHERAPY; SKIN; HEAD;

D O I：

10.1111/cup.12766

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Cutaneous squamous cell carcinoma (SCC) is a growing public health problem in the United States. A subset of high-risk SCC exhibits a more aggressive clinical trajectory including increased local recurrence and lymph node metastasis. However, there are no universally accepted criteria to help define and manage these patients. This review provides an overview of the high-risk features of cutaneous SCC, prognostic stratification of various staging systems and treatment options. It further examines the prognostic factors influencing the staging of cutaneous head and neck SCC.

引用

页码：994 / 1004

页数：11

共 73 条

[71]

Veness MJ, 2007, J BIOMED BIOTECHNOL, V2007, P1

[72] HPV 5 and 8 E6 Abrogate ATR Activity Resulting in Increased Persistence of UVB Induced DNA Damage [J].