A facile preparation of tetralins from arene-1,4-diones using titanium(IV) chloride and triethylsilane

被引：11

作者：

Li, Gang ^{[1
,2
]}

Xiao, Qiong ^{[1
,2
]}

Li, Chun ^{[1
,2
]}

Wang, Xiaojian ^{[1
,2
]}

Yin, Dali ^{[1
,2
]}

机构：

[1] Peking Union Med Coll, Dept Med Chem,Inst Mat Med, Beijing Key Lab Act Subst Discovery & Drugabil, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 50期

关键词：

Tetralin; Arene-1,4-dione; Intramolecular cyclization; Ionic hydrogenation; CONDENSED POLYNUCLEAR HYDROCARBONS; AROMATIC ALCOHOLS; CYCLODEHYDRATION; SELECTIVITY; CYCLIZATION; RECEPTOR;

D O I：

10.1016/j.tetlet.2011.10.054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile method for the synthesis of tetralins has been described which uses various substituted phenylpentane-1,4-diones as starting material with a combination of TiCl4/Et3SiH. The synthesis involves three reactions under mild conditions. A mechanism has been proposed for the reductive cyclization through ionic hydrogenation, and titanium(IV) chloride catalyzed cyclization. (C) 2011 Elsevier Ltd. All rights reserved.

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收藏

页码：6827 / 6830

页数：4

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