Non-high-density lipoprotein cholesterol and risk of cardiovascular disease in the general population and patients with type 2 diabetes: A systematic review and meta-analysis

被引：19

作者：

Cao, Yanchao ^{[1
]}

Yan, Liqiu ^{[1
]}

Guo, Nan ^{[1
]}

Yu, Na ^{[1
]}

Wang, Yunfei ^{[1
]}

Cao, Xufen ^{[1
]}

Yang, Shuping ^{[1
]}

Lv, Fengfeng ^{[1
]}

机构：

[1] Hebei Med Univ, Dept Cardiol, Cangzhou Cent Hosp, 16 Xinhua West Rd, Cangzhou 061000, Hebei, Peoples R China

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2019年 / 147卷

关键词：

Non-high-density lipoprotein cholesterol; Cardiovascular disease; Cardiovascular mortality; Meta-analysis; NON-HDL CHOLESTEROL; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-B; LIPID MEASURES; ASSOCIATION; PREDICTOR; MORTALITY; TRIGLYCERIDE; EVENTS; MEN;

D O I：

10.1016/j.diabres.2018.11.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: To examine the relationship of non-high-density lipoprotein cholesterol (non-HDL-C) level with cardiovascular disease (CVD) risk in type 2 diabetes patients and the general population by conducting a meta-analysis. Methods: We made a comprehensive literature search for relevant observational studies investigating the relationship of non-HDL-C level with CVD risk in the general population and type 2 diabetes patients using the PubMed and Embase databases. Pooled risk ratio (RR) with 95% confidence intervals (CI) was calculated for the highest versus the reference lower non-HDL-Cl. Results: A total of 13 studies with 156,381 individuals were included. The pooled RR of CVD was 1.59 (95% CI 1.46-1.72) in the general population and 1.99 (95% CI 1.57-2.51) in type 2 diabetes patients. Subgroup analysis showed the similar effect of non-HDL-C on CVD risk between men (RR1.98; 95% CI 1.70-2.30) and women (RR 1.63; 95% CI 1.35-1.96). However, elevated non-HDL-C was not associated with higher risk of cardiovascular mortality in the general population (RR 1.64; 95% CI 0.96-2.80) and type 2 diabetes patients (RR 1.08; 95% CI 0.57-2.07). Conclusions: Elevated non-HDL-C level is associated with an increased risk of CVD in the general population and type 2 diabetes patients. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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