Cladribine transfer into human milk: A case report

被引：21

作者：

Datta, Palika ^{[2
]}

Ciplea, Andrea, I ^{[1
,3
]}

Rewers-Felkins, Kathleen ^{[2
]}

Baker, Teresa ^{[4
]}

Gold, Ralf ^{[1
]}

Hale, Thomas W. ^{[2
]}

Hellwig, Kerstin ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Dept Neurol, St Josef Hosp, Gudrunstr 56, D-44791 Bochum, Germany

[2] Texas Tech Univ, Hlth Sci Ctr, Dept Pediat, Amarillo, TX USA

[3] Heinrich Heine Univ Dusseldorf, Inst Clin Pharm & Pharmacotherapy, Dusseldorf, Germany

[4] Texas Tech Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, Amarillo, TX USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2021年 / 27卷 / 05期

关键词：

Multiple sclerosis; cladribine; human milk; breastfeeding; antimetabolite; relative infant dose; MULTIPLE-SCLEROSIS; SEX-RATIO;

D O I：

10.1177/1352458520912173

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Cladribine is an antimetabolite used for the treatment of relapsing-remitting multiple sclerosis. At present, there are no data available on its use in breastfeeding mothers and its transfer in human milk. Objective: We present a case of a lactating mother who donated her milk samples to study the transfer of cladribine following a 20-mg oral dose. Methods: Analysis was done using liquid chromatography-mass spectrometry. Results: The relative infant dose calculated in this study was 3.06%. Conclusion: This is the first case report suggesting the transfer of cladribine in human milk in measurable quantities. However, caution should be advised during lactation.

引用

页码：799 / 801

页数：3

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