Background: Cladribine is an antimetabolite used for the treatment of relapsing-remitting multiple sclerosis. At present, there are no data available on its use in breastfeeding mothers and its transfer in human milk. Objective: We present a case of a lactating mother who donated her milk samples to study the transfer of cladribine following a 20-mg oral dose. Methods: Analysis was done using liquid chromatography-mass spectrometry. Results: The relative infant dose calculated in this study was 3.06%. Conclusion: This is the first case report suggesting the transfer of cladribine in human milk in measurable quantities. However, caution should be advised during lactation.
机构:
Linkoping Univ, Dept Clin & Expt Med, Div Neurosci, Fac Med, S-58183 Linkoping, SwedenLinkoping Univ, Dept Clin & Expt Med, Div Neurosci, Fac Med, S-58183 Linkoping, Sweden
Bostrom, Inger
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Stawiarz, Leszek
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机构:
Karolinska Inst, Dept Clin Neurosci, Div Neurol, S-10401 Stockholm, SwedenLinkoping Univ, Dept Clin & Expt Med, Div Neurosci, Fac Med, S-58183 Linkoping, Sweden
Stawiarz, Leszek
;
Landtblom, Anne-Marie
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机构:
Gen Hosp, Neurol Unit, Motala, Sweden
Linkoping Univ Hosp, Neurol Clin, S-58185 Linkoping, SwedenLinkoping Univ, Dept Clin & Expt Med, Div Neurosci, Fac Med, S-58183 Linkoping, Sweden
机构:
Clin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Hermann, Robert
;
Karlsson, Mats O.
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机构:
Uppsala Univ, Dept Pharmaceut Biosci, Uppsala, SwedenClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Karlsson, Mats O.
;
Novakovic, Ana M.
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h-index: 0
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Merck KGaA, Darmstadt, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Novakovic, Ana M.
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Terranova, Nadia
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h-index: 0
机构:
Merck Serono SA, Merck Inst Pharmacometr, Coinsins, Switzerland
Merck KGaA, Darmstadt, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Terranova, Nadia
;
Fluck, Markus
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h-index: 0
机构:
Merck KGaA, Darmstadt, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Fluck, Markus
;
Munafo, Alain
论文数: 0引用数: 0
h-index: 0
机构:
Merck Serono SA, Merck Inst Pharmacometr, Coinsins, Switzerland
Merck KGaA, Darmstadt, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
机构:
Linkoping Univ, Dept Clin & Expt Med, Div Neurosci, Fac Med, S-58183 Linkoping, SwedenLinkoping Univ, Dept Clin & Expt Med, Div Neurosci, Fac Med, S-58183 Linkoping, Sweden
Bostrom, Inger
;
Stawiarz, Leszek
论文数: 0引用数: 0
h-index: 0
机构:
Karolinska Inst, Dept Clin Neurosci, Div Neurol, S-10401 Stockholm, SwedenLinkoping Univ, Dept Clin & Expt Med, Div Neurosci, Fac Med, S-58183 Linkoping, Sweden
Stawiarz, Leszek
;
Landtblom, Anne-Marie
论文数: 0引用数: 0
h-index: 0
机构:
Gen Hosp, Neurol Unit, Motala, Sweden
Linkoping Univ Hosp, Neurol Clin, S-58185 Linkoping, SwedenLinkoping Univ, Dept Clin & Expt Med, Div Neurosci, Fac Med, S-58183 Linkoping, Sweden
机构:
Clin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Hermann, Robert
;
Karlsson, Mats O.
论文数: 0引用数: 0
h-index: 0
机构:
Uppsala Univ, Dept Pharmaceut Biosci, Uppsala, SwedenClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Karlsson, Mats O.
;
Novakovic, Ana M.
论文数: 0引用数: 0
h-index: 0
机构:
Merck KGaA, Darmstadt, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Novakovic, Ana M.
;
Terranova, Nadia
论文数: 0引用数: 0
h-index: 0
机构:
Merck Serono SA, Merck Inst Pharmacometr, Coinsins, Switzerland
Merck KGaA, Darmstadt, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Terranova, Nadia
;
Fluck, Markus
论文数: 0引用数: 0
h-index: 0
机构:
Merck KGaA, Darmstadt, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany
Fluck, Markus
;
Munafo, Alain
论文数: 0引用数: 0
h-index: 0
机构:
Merck Serono SA, Merck Inst Pharmacometr, Coinsins, Switzerland
Merck KGaA, Darmstadt, GermanyClin Res Appliance Cr Appliance, Heinrich Vingerhut Weg 3, D-63571 Gelnhausen, Germany