Cladribine transfer into human milk: A case report

被引:21
作者
Datta, Palika [2 ]
Ciplea, Andrea, I [1 ,3 ]
Rewers-Felkins, Kathleen [2 ]
Baker, Teresa [4 ]
Gold, Ralf [1 ]
Hale, Thomas W. [2 ]
Hellwig, Kerstin [1 ]
机构
[1] Ruhr Univ Bochum, Dept Neurol, St Josef Hosp, Gudrunstr 56, D-44791 Bochum, Germany
[2] Texas Tech Univ, Hlth Sci Ctr, Dept Pediat, Amarillo, TX USA
[3] Heinrich Heine Univ Dusseldorf, Inst Clin Pharm & Pharmacotherapy, Dusseldorf, Germany
[4] Texas Tech Univ, Dept Obstet & Gynecol, Hlth Sci Ctr, Amarillo, TX USA
关键词
Multiple sclerosis; cladribine; human milk; breastfeeding; antimetabolite; relative infant dose; MULTIPLE-SCLEROSIS; SEX-RATIO;
D O I
10.1177/1352458520912173
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Cladribine is an antimetabolite used for the treatment of relapsing-remitting multiple sclerosis. At present, there are no data available on its use in breastfeeding mothers and its transfer in human milk. Objective: We present a case of a lactating mother who donated her milk samples to study the transfer of cladribine following a 20-mg oral dose. Methods: Analysis was done using liquid chromatography-mass spectrometry. Results: The relative infant dose calculated in this study was 3.06%. Conclusion: This is the first case report suggesting the transfer of cladribine in human milk in measurable quantities. However, caution should be advised during lactation.
引用
收藏
页码:799 / 801
页数:3
相关论文
共 7 条
[1]   Sex ratio of multiple sclerosis in the National Swedish MS Register (SMSreg) [J].
Bostrom, Inger ;
Stawiarz, Leszek ;
Landtblom, Anne-Marie .
MULTIPLE SCLEROSIS JOURNAL, 2013, 19 (01) :46-52
[2]  
EMA, MAV CLADR SUMM PROD
[3]  
FDA, 2019, MAV CLADR FULL PRESC
[4]   The Clinical Pharmacology of Cladribine Tablets for the Treatment of Relapsing Multiple Sclerosis [J].
Hermann, Robert ;
Karlsson, Mats O. ;
Novakovic, Ana M. ;
Terranova, Nadia ;
Fluck, Markus ;
Munafo, Alain .
CLINICAL PHARMACOKINETICS, 2019, 58 (03) :283-297
[5]   Sex ratio of multiple sclerosis in Canada: a longitudinal study [J].
Orton, Sarah-Michelle ;
Herrera, Blanca M. ;
Yee, Irene M. ;
Valdar, William ;
Ramagopalan, Sreeram V. ;
Sadovnick, A. Dessa ;
Ebers, George C. .
LANCET NEUROLOGY, 2006, 5 (11) :932-936
[6]   Comparison of the in vitro and in vivo metabolism of Cladribine (Leustatin, Movectro) in animals and human [J].
Scheible, Holger ;
Laisney, Marc ;
Wimmer, Elmar ;
Javornik, Ana ;
Dolgos, Hugues .
XENOBIOTICA, 2013, 43 (12) :1084-1094
[7]   Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment [J].
Troussard, Xavier ;
Cornet, Edouard .
AMERICAN JOURNAL OF HEMATOLOGY, 2017, 92 (12) :1382-1390