Towards a Comprehensive Understanding of UA-ADRCs (Uncultured, Autologous, Fresh, Unmodified, Adipose Derived Regenerative Cells, Isolated at Point of Care) in Regenerative Medicine

被引：23

作者：

Alt, Eckhard U.

Winnier, Glenn

Haenel, Alexander

Rothoerl, Ralf

Solakoglu, Oender

Alt, Christopher

Schmitz, Christoph

机构：

[1] Heart and Vascular Institute, Department of Medicine, Tulane University Health Science Center, New Orleans

[2] Sanford Health, University of South Dakota, Sioux Falls

[3] University of Texas MD Anderson Cancer Center, Houston

[4] Munich

[5] InGeneron, Inc., Houston

[6] Department of Radiology and Nuclear Medicine, University Hospital Schleswig-Holstein

[7] Dental Department of the University Medical Center Hamburg-Eppendorf, 20246, Hamburg

[8] Periodontology and Implant Dentistry, 22453, Hamburg

[9] InGeneron GmbH, Munich

[10] Institute of Anatomy, Faculty of Medicine, LMU Munich, Munich

来源：

CELLS | 2020年 / 9卷 / 05期

关键词：

stem cells; adipose tissue derived regenerative cells; ADRCs; point of care treatment; randomized controlled trials; safety; efficacy; stromal vascular fraction; review; STROMAL-VASCULAR FRACTION; MESENCHYMAL STEM-CELLS; PLATELET-RICH PLASMA; MICROVASCULAR PERICYTES; INTERNATIONAL-SOCIETY; TISSUE; THERAPY; COMPLICATION; LIPOSUCTION; MECHANISMS;

D O I：

10.3390/cells9051097

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It has become practically impossible to survey the literature on cells derived from adipose tissue for regenerative medicine. The aim of this paper is to provide a comprehensive and translational understanding of the potential of UA-ADRCs (uncultured, unmodified, fresh, autologous adipose derived regenerative cells isolated at the point of care) and its application in regenerative medicine. We provide profound basic and clinical evidence demonstrating that tissue regeneration with UA-ADRCs is safe and effective. ADRCs are neither 'fat stem cells' nor could they exclusively be isolated from adipose tissue. ADRCs contain the same adult stem cells ubiquitously present in the walls of blood vessels that are able to differentiate into cells of all three germ layers. Of note, the specific isolation procedure used has a significant impact on the number and viability of cells and hence on safety and efficacy of UA-ADRCs. Furthermore, there is no need to specifically isolate and separate stem cells from the initial mixture of progenitor and stem cells found in ADRCs. Most importantly, UA-ADRCs have the physiological capacity to adequately regenerate tissue without need for more than minimally manipulating, stimulating and/or (genetically) reprogramming the cells for a broad range of clinical applications. Tissue regeneration with UA-ADRCs fulfills the criteria of homologous use as defined by the regulatory authorities.

引用

页数：23

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