Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19

被引:9
作者
Kang, Min-Kyu [1 ]
Lee, Yu-Rim [2 ]
Song, Jeung-Eun [3 ]
Kweon, Young-Oh [2 ]
Tak, Won-Young [2 ]
Jang, Se-Young [2 ]
Park, Jung-Gil [1 ]
Park, Soo-Young [2 ]
机构
[1] Yeungnam Univ, Dept Internal Med, Coll Med, Daegu 42415, South Korea
[2] Kyungpook Natl Univ, Dept Internal Med, Sch Med, Kyungpook Natl Univ Hosp, Daegu 41994, South Korea
[3] Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu 42472, South Korea
基金
新加坡国家研究基金会;
关键词
COVID-19; myosteatosis; visceral adiposity; sarcopenia; body composition; CORONAVIRUS DISEASE 2019; SARCOPENIA; MULTICENTER; OUTCOMES;
D O I
10.3390/diagnostics12092255
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Body composition, including sarcopenia, adipose tissue, and myosteatosis, is associated with unfavorable clinical outcomes in patients with coronavirus disease (COVID-19). However, few studies have identified the impact of body composition, including pre-existing risk factors, on COVID-19 mortality. Therefore, this study aimed to evaluate the effect of body composition, including pre-existing risk factors, on mortality in hospitalized patients with COVID-19. This two-center retrospective study included 127 hospitalized patients with COVID-19 who underwent unenhanced chest computed tomography (CT) between February and April 2020. Using the cross-sectional CT images at the L2 vertebra level, we analyzed the body composition, including skeletal muscle mass, visceral to subcutaneous adipose tissue ratio (VSR), and muscle density using the Hounsfield unit (HU). Of 127 patients with COVID-19, 16 (12.6%) died. Compared with survivors, non-survivors had low muscle density (41.9 vs. 32.2 HU, p < 0.001) and high proportion of myosteatosis (4.5 vs. 62.5%, p < 0.001). Cox regression analyses revealed diabetes (hazard ratio [HR], 3.587), myosteatosis (HR, 3.667), and a high fibrosis-4 index (HR, 1.213) as significant risk factors for mortality in patients with COVID-19. Myosteatosis was associated with mortality in hospitalized patients with COVID-19, independent of pre-existing prognostic factors.
引用
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页数:12
相关论文
共 40 条
[1]   European Working Group on Sarcopenia in Older People (EWGSOP2) Criteria With Population-Based Skeletal Muscle Index Best Predicts Mortality in Asians With Cirrhosis [J].
Anand, Abhinav ;
Mohta, Srikant ;
Agarwal, Samagra ;
Sharma, Sanchit ;
Gopi, Srikanth ;
Gunjan, Deepak ;
Madhusudhan, Kumble S. ;
Singh, Namrata ;
Saraya, Anoop .
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY, 2022, 12 (01) :52-60
[2]   Computed tomography reference values for visceral obesity and increased metabolic risk in a Caucasian cohort [J].
Baggerman, Michelle R. ;
Dekker, Ingeborg M. ;
Winkens, Bjorn ;
Damink, Steven W. M. Olde ;
Weijs, Peter J. M. ;
van de Poll, Marcel C. G. .
CLINICAL NUTRITION ESPEN, 2022, 48 :408-413
[3]   Computed Tomography Highlights Increased Visceral Adiposity Associated With Critical Illness in COVID-19 [J].
Battisti, Sofia ;
Pedone, Claudio ;
Napoli, Nicola ;
Russo, Emanuele ;
Agnoletti, Vanni ;
Nigra, Stefano Geniere ;
Dengo, Caterina ;
Mughetti, Martina ;
Conte, Caterina ;
Pozzilli, Paolo ;
Giampalma, Emanuela ;
Strollo, Rocky .
DIABETES CARE, 2020, 43 (10) :E129-E130
[4]   The deterioration of muscle mass and radiodensity is prognostic of poor survival in stage I-III colorectal cancer: a population-based cohort study (C-SCANS) [J].
Brown, Justin C. ;
Caan, Bette J. ;
Meyerhardt, Jeffrey A. ;
Weltzien, Erin ;
Xiao, Jingjie ;
Feliciano, Elizabeth M. Cespedes ;
Kroenke, Candyce H. ;
Castillo, Adrienne ;
Kwan, Marilyn L. ;
Prado, Carla M. .
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 2018, 9 (04) :664-672
[5]   A multicenter study to define sarcopenia in patients with end-stage liver disease [J].
Carey, Elizabeth J. ;
Lai, Jennifer C. ;
Wang, Connie W. ;
Dasarathy, Srinivasan ;
Lobach, Iryna ;
Montano-Loza, Aldo J. ;
Dunn, Michael A. .
LIVER TRANSPLANTATION, 2017, 23 (05) :625-633
[6]   Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis [J].
Corona, Giovanni ;
Pizzocaro, Alessandro ;
Vena, Walter ;
Rastrelli, Giulia ;
Semeraro, Federico ;
Isidori, Andrea M. ;
Pivonello, Rosario ;
Salonia, Andrea ;
Sforza, Alessandra ;
Maggi, Mario .
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2021, 22 (02) :275-296
[7]   Myosteatosis Significantly Predicts Persistent Dyspnea and Mobility Problems in COVID-19 Survivors [J].
De Lorenzo, Rebecca ;
Palmisano, Anna ;
Esposito, Antonio ;
Gnasso, Chiara ;
Nicoletti, Valeria ;
Leone, Riccardo ;
Vignale, Davide ;
Falbo, Elisabetta ;
Ferrante, Marica ;
Cilla, Marta ;
Magnaghi, Cristiano ;
Martinenghi, Sabina ;
Vitali, Giordano ;
Molfino, Alessio ;
Rovere-Querini, Patrizia ;
Muscaritoli, Maurizio ;
Conte, Caterina .
FRONTIERS IN NUTRITION, 2022, 9
[8]   Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible Therapeutic Measures [J].
Esther Rubio-Ruiz, Maria ;
Guarner-Lans, Veronica ;
Perez-Torres, Israel ;
Elena Soto, Maria .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (03)
[9]   Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma [J].
Fujiwara, Naoto ;
Nakagawa, Hayato ;
Kudo, Yotaro ;
Tateishi, Ryosuke ;
Taguri, Masataka ;
Watadani, Takeyuki ;
Nakagomi, Ryo ;
Kondo, Mayuko ;
Nakatsuka, Takuma ;
Minami, Tatsuya ;
Sato, Masaya ;
Uchino, Koji ;
Enooku, Kenichiro ;
Kondo, Yuji ;
Asaoka, Yoshinari ;
Tanaka, Yasuo ;
Ohtomo, Kuni ;
Shiina, Shuichiro ;
Koike, Kazuhiko .
JOURNAL OF HEPATOLOGY, 2015, 63 (01) :131-140
[10]   Obesity Is a Risk Factor for Greater COVID-19 Severity [J].
Gao, Feng ;
Zheng, Kenneth I. ;
Wang, Xiao-Bo ;
Sun, Qing-Feng ;
Pan, Ke-Hua ;
Wang, Ting-Yao ;
Chen, Yong-Ping ;
Targher, Giovanni ;
Byrne, Christopher D. ;
George, Jacob ;
Zheng, Ming-Hua .
DIABETES CARE, 2020, 43 (07) :E72-E74