Pyrazoles, isoxazoles, and 1,2,3-triazoles as analogs of the natural cytostatic combretastatin A-4: efficient routes of synthesis, tubulin inhibition, and cytotoxicity

被引：1

作者：

Kostin, Roman K. ^{[1
]}

Marshavin, Aleksander S. ^{[2
]}

机构：

[1] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Minist Hlth Russian Federat, 8,Bldg 2 Trubetskaya St, Moscow 119991, Russia

[2] Lomonosov Moscow State Univ, 1,Bldg 3 Leninskie Gory, Moscow 119991, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2021年 / 57卷 / 11期

关键词：

combretastatin A-4; combretastatin analogs; 3,5-diarylisoxazole; heterocycles; pyrazole; pyrazoline; 1,2,3-triazole; tubulin; cytotoxicity; tubulin-binding agents; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; POLYMERIZATION INHIBITORS; STRUCTURAL BASIS; COLCHICINE SITE; POTENT; DERIVATIVES; BINDING; DESIGN; AGENTS;

D O I：

10.1007/s10593-021-03025-y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The review discusses the advantages and disadvantages of combretastatin A-4, presents the most effective methods for the synthesis of its 1,2,3-triazole, pyrazole, isoxazole analogs. The structural formulas of the analogs of combretastatin A-4 which are the most active against cancer cells, together with indicators of cytotoxicity, are also presented.

引用

页码：1061 / 1072

页数：12

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