First Outbreak of a Plasmid-Mediated Carbapenem-Hydrolyzing OXA-48 β-Lactamase in Klebsiella pneumoniae in Spain

被引：117
作者：
Pitart, Cristina
Sole, Mar
Roca, Ignasi
Fabrega, Anna
Vila, Jordi
Marco, Francesc
机构：
[1] Univ Barcelona, Dept Clin Microbiol, Sch Med, Hosp Clin IDIBAPS, Barcelona, Spain
[2] Barcelona Ctr Int Hlth Res, Barcelona, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 09期
关键词：
RESISTANCE; EMERGENCE; IMIPENEM; SPREAD; TURKEY; GENES;
D O I：
10.1128/AAC.00329-11
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Twenty Klebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 beta-lactamase. A conjugative plasmid of circa 70 kb carrying bla OXA-48 was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producing K. pneumoniae strain in Spain.
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收藏
页码：4398 / 4401
页数：4
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