Categorical and dimensional psychopathology in Dutch and US offspring of parents with bipolar disorder: A preliminary cross-national comparison

被引：33

作者：

Mesman, Esther ^{[1
]}

Birmaher, Boris B. ^{[2
]}

Goldstein, Benjamin I. ^{[3
]}

Goldstein, Tina ^{[2
]}

Derks, Eske M. ^{[4
]}

Vleeschouwer, Marloes ^{[1
]}

Hickey, Mary Beth ^{[2
]}

Axelson, David ^{[5
,6
]}

Monk, Kelly ^{[2
]}

Diler, Rasim ^{[2
]}

Hafeman, Danella ^{[2
]}

Sakolsky, Dara J. ^{[2
]}

Reichart, Catrien G. ^{[7
]}

Wals, Marjolein ^{[9
]}

Verhulst, Frank C. ^{[8
]}

Nolen, Willem A. ^{[10
]}

Hillegers, Manon H. J. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, A00-241,POB 85500, NL-3508 GA Utrecht, Netherlands

[2] Univ Pittsburgh, Med Ctr, Dept Psychiat, Pittsburgh, PA USA

[3] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Psychiat, Toronto, ON, Canada

[4] Acad Med Ctr, Dept Psychiat, Amsterdam, Netherlands

[5] Nationswide Childrens Hosp, Dept Psychiat, Columbus, OH USA

[6] Ohio State Coll Med, Columbus, OH USA

[7] Leiden Univ, Curium, Med Ctr, Leiden, Netherlands

[8] Erasmus Univ, Sophia Childrens Hosp, Med Ctr, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands

[9] Erasmus Univ, Inst Psychol, Rotterdam, Netherlands

[10] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands

来源：

JOURNAL OF AFFECTIVE DISORDERS | 2016年 / 205卷

关键词：

Bipolar offspring; High risk; Cross-national; Bipolar disorder; Mood disorder; Child Behavior Checklist; UNITED-STATES; CHILDREN; ADOLESCENTS; AGE; HISTORY; ONSET; EPIDEMIOLOGY; ASSOCIATION; RELIABILITY; PREVALENCE;

D O I：

10.1016/j.jad.2016.06.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Accumulating evidence suggests cross-national differences in adults with bipolar disorder (BD), but also in the susceptibility of their offspring (bipolar offspring). This study aims to explore and clarify cross-national variation in the prevalence of categorical and dimensional psychopathology between bipolar offspringin the US and The Netherlands. Methods: We compared levels of psychopathology in offspring of the Pittsburgh Bipolar Offspring Study (n=224) and the Dutch Bipolar Offspring Study (n=136) (age 10-18). Categorical psychopathology was ascertained through interviews using the Schedule for Affective Disorders and Schizophrenia for School Age Children (K-SADS-PL), dimensional psychopathology by parental reports using the Child Behavior Checklist (CBCL). Results: Higher rates of categorical psychopathology were observed in the US versus the Dutch samples (66% versus 44%). We found no differences in the overall prevalence of mood disorders, including BD-I or -II, but more comorbidity in mood disorders in US versus Dutch off spring (80% versus 34%). The strongest predictors of categorical psychopathology were maternal BD (OR: 1.72, p<.05), older age of the offspring (OR: 1.19, p<.05), and country of origin (US; OR: 2.17, p<.001). Regarding comorbidity, only country of origin (OR: 7.84, p<.001) was a significant predictor. Ingeneral, we found no differences in dimensional psychopathology based on CBCL reports. Limitations: Preliminary measure of inter-site reliability. Conclusions: We found cross-national differences in prevalence of categorical diagnoses of non-mood disorders in bipolar offspring, but not in mood disorder diagnoses nor in parent-reported dimensional psychopathology. Cross-national variation was only partially explained by between-sample differences. Cultural and methodological explanations for these findings warrant further study. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：95 / 102

页数：8

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