Rapamycin-induced posterior reversible encephalopathy in a kidney transplantation patient

被引：17

作者：

Qin, Wei ^{[1
]}

Tan, Chun Yu ^{[2
]}

Huang, Xiaoqi ^{[3
]}

Huang, Zixing ^{[3
]}

Tao, Ye ^{[1
]}

Fu, Ping ^{[1
]}

机构：

[1] Sichuan Univ, Div Nephrol, Dept Med, W China Hosp, Chengdu 610064, Peoples R China

[2] Sichuan Univ, Div Rheumatol & Immunol, W China Hosp, Chengdu 610064, Peoples R China

[3] Sichuan Univ, Div Radiol, W China Hosp, Chengdu 610064, Peoples R China

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2011年 / 43卷 / 03期

关键词：

PRES; Rapamycin; Kidney transplantation; LEUKOENCEPHALOPATHY SYNDROME;

D O I：

10.1007/s11255-010-9757-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Posterior reversible encephalopathy syndrome (PRES) is characterized by abnormalities in cerebral white matter and neurologic symptoms. It can be caused by immunosuppressive drugs or autoimmune diseases. We describe a case of PRES in a kidney transplantation patient treated with rapamycin. A 24-year-old woman, who received kidney transplantation 8 years ago, presented hypertension (220/120 mmHg), blindness, paralysis of left extremities, vomiting, convulsions and unconsciousness after rapamycin treatment. Magnetic resonance imaging (MRI) showed brain lesions suggestive of PRES. Rapamycin was withdrawn, and repeated MRI indicated progressive resolution within 2 months. Although neurotoxicity of rapamycin is relatively low, it can induce PRES in kidney transplantation patients.

引用

页码：913 / 916

页数：4

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