Reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia

被引：7

作者：

Lekakis, Lazaros ^{[2
]}

de Lima, Marcos ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA

[2] Univ Kentucky, Dept Hematol Med Oncol & Blood & Marrow Transplan, Markey Canc Ctr, Lexington, KY 40536 USA

来源：

EXPERT REVIEW OF ANTICANCER THERAPY | 2008年 / 8卷 / 05期

关键词：

acute myeloid leukemia; allogeneic stem cell transplantation; nonmyeloablative; reduced-intensity conditioning;

D O I：

10.1586/14737140.8.5.785

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) is a hematologic malignancy with a peak incidence over the age of 55 years. AML of older patients is less curable with conventional chemotherapy, and, when it relapses, is almost uniformly fatal. Novel treatments hold the promise of improving the results of therapy, but have failed so far to show dramatic change in the prognosis. Allogeneic stem cell transplantation using traditional myeloablative preparative regimens is not easily tolerated by the elderly and/or frailer patient, and may lead to prohibitive treatment-related mortality rates. Most patients treated in the past were younger and devoid of comorbid clinical conditions. Novel reduced-intensity regimens made allogeneic transplants applicable to the elderly, providing the benefit of the graft-versus-leukemia effect to a larger number of patients in need. Here we review the indications for allogeneic transplants in AML and discuss reduced-intensity conditioning regimens.

引用

页码：785 / 798

页数：14

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[31] Targeted Marrow Irradiation Intensification of Reduced-Intensity Fludarabine/Busulfan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation [J].

Ali, Naveed ;

Sharma, Ashish Arunkumar ;

Pires de Rezende, Ana Carolina ;

Otegbeye, Folashade ;

Latif, Bilal Muhammad ;

Kerbauy, Mariana Nassif ;

Cooper, Brenda W. ;

Sanchez, Gabriela ;

Metheny, Leland ;

Bal, Saswat K. ;

Sakuraba, Roberto ;

Tomlinson, Benjamin K. ;

Boughan, Kirsten M. ;

Kerbauy, Lucila ;

Malek, Ehsan ;

Ribeiro, Andreza Feitosa ;

Gallogly, Molly ;

Mansur, David ;

Pereira, Gisele ;

Weltman, Eduardo ;

Sekaly, Rafick-Pierre ;

de Lima, Marcos ;

Caimi, Paolo F. ;

Hamerschlak, Nelson .

TRANSPLANTATION AND CELLULAR THERAPY, 2022, 28 (07) :370.e1-370.e10

[32] Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia:: disease status by marrow blasts is the strongest prognostic factor [J].

Sayer, HG ;

Kröger, M ;

Beyer, J ;

Kiehl, M ;

Klein, SA ;

Schaefer-Eckart, K ;

Schwerdtfeger, R ;

Siegert, W ;

Runde, V ;

Theuser, C ;

Martin, H ;

Schetelig, J ;

Beelen, DW ;

Fauser, A ;

Kienast, J ;

Höffken, K ;

Ehninger, G ;

Bornhäuser, M .

BONE MARROW TRANSPLANTATION, 2003, 31 (12) :1089-1095

[33] Reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia: disease status by marrow blasts is the strongest prognostic factor [J].

H G Sayer ;

M Kröger ;

J Beyer ;

M Kiehl ;

S A Klein ;

K Schaefer-Eckart ;

R Schwerdtfeger ;

W Siegert ;

V Runde ;

C Theuser ;

H Martin ;

J Schetelig ;

D W Beelen ;

A Fauser ;

J Kienast ;

K Höffken ;

G Ehninger ;

M Bornhäuser .

Bone Marrow Transplantation, 2003, 31 :1089-1095

[34] Allogeneic hematopoietic stem cell transplantation (HSCT) after reduced intensity conditioning [J].

Servais, Sophie ;

Baron, Frederic ;

Beguin, Yves .

TRANSFUSION AND APHERESIS SCIENCE, 2011, 44 (02) :205-210

[35] Impact of Postremission Consolidation Chemotherapy on Outcome After Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation for Patients With Acute Myeloid Leukemia in First Complete Remission [J].

Yeshurun, Moshe ;

Labopin, Myriam ;

Blaise, Didier ;

Cornelissen, Jan J. ;

Sengeloev, Henrik ;

Vindelov, Lars ;

Kuball, Juergen ;

Chevallier, Patrice ;

Craddock, Charles ;

Socie, Gerard ;

Bilger, Karin ;

Schouten, Harry C. ;

Fegueux, Nathalie ;

Goker, Hakan ;

Maertens, Johan ;

Bunjes, Donald ;

Arnold, Renate ;

Nagler, Arnon ;

Mohty, Mohamad .

CANCER, 2014, 120 (06) :855-863

[36] Prognostic impact of melphalan dose and total body irradiation use in patients with acute myeloid leukemia undergoing allogeneic stem cell transplantation with reduced-intensity conditioning [J].

Harada, Kaito ;

Yanada, Masamitsu ;

Machida, Shinichiro ;

Kanamori, Heiwa ;

Onizuka, Makoto ;

Ozawa, Yukiyasu ;

Kobayashi, Hikaru ;

Sawa, Masashi ;

Katayama, Yuta ;

Ohashi, Kazuteru ;

Kanda, Junya ;

Ichinohe, Tatsuo ;

Atsuta, Yoshiko ;

Yano, Shingo .

LEUKEMIA & LYMPHOMA, 2019, 60 (06) :1493-1502

[37] Reduced-Intensity Conditioning Regimens for Allogeneic Transplantation in Children with Acute Lymphoblastic Leukemia [J].

Verneris, Michael R. ;

Eapen, Mary ;

Duerst, Reggie ;

Carpenter, Paul A. ;

Burke, Michael J. ;

Afanasyev, B. V. ;

Cowan, Morton J. ;

He, Wensheng ;

Krance, Robert ;

Li, Chi-Kong ;

Tan, Poh-Lin ;

Wagner, John E. ;

Davies, Stella M. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (09) :1237-1244

[38] Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome [J].

Shiratori, Souichi ;

Fujimoto, Katsuya ;

Nishimura, Machiko ;

Hatanaka, Kanako C. ;

Kosugi-Kanaya, Mizuha ;

Okada, Kohei ;

Sugita, Junichi ;

Shigematsu, Akio ;

Hashimoto, Daigo ;

Endo, Tomoyuki ;

Kondo, Takeshi ;

Abe, Riichiro ;

Hashino, Satoshi ;

Matsuno, Yoshihiro ;

Shimizu, Hiroshi ;

Teshima, Takanori .

HEMATOLOGICAL ONCOLOGY, 2016, 34 (01) :9-16

[39] Reduced-Intensity Conditioning in Allogeneic Stem Cell Transplantation for Hematological Malignancies: A Historical Perspective [J].

Cremer, Birgit ;

Sandmaier, Brenda M. ;

Bethge, Wolfgang ;

Lange, Thoralf ;

Goede, Valentin ;

Holtick, Udo ;

Hallek, Michael ;

Huebel, Kai .

ONKOLOGIE, 2011, 34 (12) :710-715

[40] Fludarabine with cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with poor-risk chronic lymphocytic leukemia [J].

Krejci, Marta ;

Doubek, Michael ;

Brychtova, Yvona ;

Stehlikova, Olga ;

Chovancova, Jana ;

Tichy, Boris ;

Francova, Hana Skuhrova ;

Navratil, Milan ;

Tomiska, Miroslav ;

Horky, Ondrej ;

Pospisilova, Sarka ;

Mayer, Jiri .

ANNALS OF HEMATOLOGY, 2013, 92 (02) :249-254

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