Novel Cobalt Bis(dicarbollide) Based on Terminal Alkynes and Their Click-Reactions

被引：11

作者：

Druzina, Anna A. ^{[1
]}

Kosenko, Irina D. ^{[1
]}

Zhidkova, Olga B. ^{[1
]}

Ananyev, Ivan V. ^{[1
,2
]}

Timofeev, Sergey V. ^{[1
]}

Bregadze, Vladimir I. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Vavilov Str 28, Moscow 119991, Russia

[2] Natl Res Univ Higher Sch Econ, Myasnitskaya Str 20, Moscow 101000, Russia

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2020年 / 2020卷 / 27期

基金：

俄罗斯基础研究基金会;

关键词：

Alkynes; Cholesterol; Click" reaction; Cobalt and iron bis(dicarbollide); Lipids; Metallacarboranes; Polyhedral boron hydrides; X-ray diffraction studies; NEUTRON-CAPTURE THERAPY; MEDICINAL CHEMISTRY; BORON; DERIVATIVES; CYCLOADDITION; ANION; METALLACARBORANES; PHARMACOPHORES; LIGATION; DELIVERY;

D O I：

10.1002/ejic.202000388

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Novel cobalt bis(dicarbollide) terminal alkynes with charge-compensated group were synthesized by the cleavage reactions of oxonium derivatives of cobalt bis(dicarbollide) with N,N-dimethylprop-2-yn-1-amine. The solid-state molecular structures of alkynes prepared from 1,4-dioxane and tetrahydropyran derivatives of cobalt and iron bis(dicarbollide) were determined by single-crystal X-ray diffraction. A series of zwitterionic conjugates of cobalt/iron bis(dicarbollide) with cholesterol were prepared using the copper(I)-catalyzed azide-alkyne cycloaddition reaction.

引用

页码：2658 / 2665

页数：8

共 76 条

[1] Toward reliable density functional methods without adjustable parameters: The PBE0 model [J].