Mechanism of interferon action - Sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones

被引：7

作者：

Kuhen, KL

Shen, XY

Samuel, CE

机构：

[1] UNIV CALIF SANTA BARBARA,DEPT MOL CELLULAR & DEV BIOL,SANTA BARBARA,CA 93106

[2] UNIV CALIF SANTA BARBARA,INTERDEPT GRAD PROGRAM BIOCHEM & MOL BIOL,SANTA BARBARA,CA 93106

来源：

GENE | 1996年 / 178卷 / 1-2期

关键词：

translational control; protein synthesis initiation factor elF-2 alpha; RNA-binding protein; antiviral protein; tumor suppressor; nucleotide sequencing;

D O I：

10.1016/0378-1119(96)00314-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The pkr gene encoding the interferon-inducible, RNA-dependent protein kinase was isolated as lambda phage and P1 phage clones from human genomic DNA and characterized by restriction mapping, Southern blot analysis, and nucleotide sequencing. The genomic nucleotide sequence, when compared to that of previously determined cDNA sequences, revealed 17 exons encoding the 551-amino-acid PKR protein. We report herein the sequence of the human PKR protein kinase deduced from genomic clones.

引用

页码：191 / 193

页数：3

共 12 条

[1]

Clemens MJ, 1996, TRANSLATIONAL CONTRO, P139

[2]

HERSHEY JWB, 1991, ANNU REV BIOCHEM, V60, P715

[3] Structural organization of the human gene (PKR) encoding an interferon-inducible RNA-Dependent protein kinase (PKR) and differences from its mouse homolog [J].