Microtubule-stabilizing agents: a growing class of important anticancer drugs

被引：127
作者：
Altmann, KH [1 ]
机构：
[1] Novartis Pharma AG, Corp Res, CH-4002 Basel, Switzerland
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 04期
关键词：
D O I：
10.1016/S1367-5931(00)00225-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Microtubule-stabilizing agents continue to play an important role in anticancer drug discovery and development. New agents were again discovered in the past year, including small synthetic molecules. At least three new taxanes and two compounds of the epothilone class of natural products underwent clinical trials in 2000. Unexpected new findings about synergistic effects between different microtubule-stabilizing agents in vitro raise new prospects for combination chemotherapy.
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页码：424 / 431
页数：8
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