Oral administration of prednisone to control refractory vertigo in a pilot Meniere's disease: A pilot study

Objective: To establish whether the oral administration of moderate doses of prednisone reduces refractory vertigo in Meniere's disease. Study Design: Blinded, randomized, controlled trial. Setting: Tertiary referral center. Patients: Patients with Meniere's disease with limited vertigo control (Class C) and severe disability (Scale 3). Interventions: Two groups (n = 8 per group) were treated orally with either diphenidol (25 mg/d) plus acetazolamide (250 mg/48 h) (control group), or the same treatment plus prednisone (0.35 mg/kg) daily for 18 weeks (prednisone group). Main Outcome Measures: The variables evaluated were the frequency and duration of vertigo, tinnitus, aural fullness, and audiographic parameters. The clinical surveillance was performed for 12 months after prednisone withdrawal. Results: The frequency and duration of vertigo episodes were reduced by 50% and 30%, respectively, by prednisone treatment. Prednisone-treated patients manifested a significant reduction in tinnitus. No changes were observed in aural fullness or hearing. No metabolic or infectious disorders were observed. Conclusion: Oral prednisone helps to control refractory vertigo in Meniere's disease. These preliminary data suggest that prednisone can be a good noninvasive antivertigo management regimen for these patients.