One-Pot Two-Step Strategy for Efficient Synthesis of 3-Aryl-4-(arylthio)-1H-pyrazol-5-amines Derivatives

被引：7

作者：

Feng Yijiao ^{[1
]}

He Jing ^{[1
]}

Wei Yueting ^{[1
]}

Tang Ting ^{[2
]}

Li Chuntian ^{[1
]}

Liu Ping ^{[1
]}

机构：

[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832000, Xinjiang, Peoples R China

[2] Shihezi Univ, Anal & Testing Ctr, Shihezi 832000, Xinjiang, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 01期

基金：

中国国家自然科学基金;

关键词：

one-pot two-step; 1H-pyrazol-5-amine; cyclization; sulfenylation; INDOLYL ARYL SULFONES; S BOND FORMATION; BIOLOGICAL EVALUATION; MULTICOMPONENT REACTIONS; INHIBITORS; PYRAZOLES; SULFENYLATION; CYCLIZATION; CORROSION; FUNCTIONALIZATION;

D O I：

10.6023/cjoc202107045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

One-pot two-step reaction of 3-oxo-3-arylpropanenitriles, methyl hydrazinecarboxvlate (or hydrazine hydrate), and arvlsulfonyl hydrazides has been established, and a series of 3-aryl-4-(arylthio)-1H-pyrazol-5-amines were constructed by sequential cvclization, sulfenvlation, and removal of COOMe group under the action of 12 and N-iodo-succininide (NIS), respectively. The method represents good atomic economy, mild reaction conditions, broad substrate scope, and gram-scale synthesis. Moreover, the further transformations of 3-aryl-4-(arylthio)-1H-pyrazol-5-amine products were also investigated.

引用

页码：226 / 234

页数：9

共 79 条

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