SARS-CoV-2 can induce brain and spine demyelinating lesions

被引：271

作者：

Zanin, Luca ^{[1
]}

Saraceno, Giorgio ^{[1
]}

Panciani, Pier Paolo ^{[1
]}

Renisi, Giulia ^{[2
]}

Signorini, Liana ^{[2
]}

Migliorati, Karol ^{[1
]}

Fontanella, Marco Maria ^{[1
]}

机构：

[1] Univ Brescia, Dept Med & Surg Specialties, Radiol Sci & Publ Hlth, Neurosurg,Spedali Civili Brescia, Piazzale Spedali Civili 1, Brescia 25124, Italy

[2] Univ Brescia, Dept Infect & Trop Dis, Brescia, Italy

来源：

ACTA NEUROCHIRURGICA | 2020年 / 162卷 / 07期

关键词：

COVID-19; SARS-CoV-2; Demyelinating lesions; Seizures; Immune response; Neuro-COVID; INFECTION;

D O I：

10.1007/s00701-020-04374-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

SARS-CoV-2 can attack the central nervous system in the early stages of infection. Headache, anosmia, and dysgeusia are common symptoms. Disturbance of consciousness and seizures can occur as complications in case of severe COVID-19. We described the case of a COVID-19 patient admitted for interstitial pneumonia and seizures. MRI showed newly diagnosed demyelinating lesions. High-dose steroid treatment allowed neurological and respiratory recovery. We speculated a delayed immune response induced by SARS-CoV-2. The virus may lead to a SIRS-like immune disorder or play a role of infective trigger. Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries.

引用

页码：1491 / 1494

页数：4

共 21 条

[1] Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms [J].

Baig, Abdul Mannan ;

Khaleeq, Areeba ;

Ali, Usman ;

Syeda, Hira .

ACS CHEMICAL NEUROSCIENCE, 2020, 11 (07) :995-998

[2] Could Sars-coronavirus-2 trigger autoimmune and/or autoinflammatory mechanisms in genetically predisposed subjects? [J].

Caso, Francesco ;

Costa, Luisa ;

Ruscitti, Piero ;

Navarini, Luca ;

Del Puente, Antonio ;

Giacomelli, Roberto ;

Scarpa, Raffaele .

AUTOIMMUNITY REVIEWS, 2020, 19 (05)

[3]

Chen C, 2020, Zhonghua Shao Shang Za Zhi, V36, P471, DOI 10.3760/cma.j.cn501120-20200224-00088

[4] Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (Publication with Expression of Concern) [J].

Corman, Victor M. ;

Landt, Olfert ;

Kaiser, Marco ;

Molenkamp, Richard ;

Meijer, Adam ;

Chu, Daniel K. W. ;

Bleicker, Tobias ;

Bruenink, Sebastian ;

Schneider, Julia ;

Schmidt, Marie Luisa ;

Mulders, Daphne G. J. C. ;

Haagmans, Bart L. ;

van der Veer, Bas ;

van den Brink, Sharon ;

Wijsman, Lisa ;

Goderski, Gabriel ;

Romette, Jean-Louis ;

Ellis, Joanna ;

Zambon, Maria ;

Peiris, Malik ;

Goossens, Herman ;

Reusken, Chantal ;

Koopmans, Marion P. G. ;

Drosten, Christian .

EUROSURVEILLANCE, 2020, 25 (03) :23-30

[5] Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? [J].

Desforges, Marc ;

Le Coupanec, Alain ;

Dubeau, Philippe ;

Bourgouin, Andreanne ;

Lajoie, Louise ;

Dube, Mathieu ;

Talbot, Pierre J. .

VIRUSES-BASEL, 2020, 12 (01)

[6] Multiple organ infection and the pathogenesis of SARS [J].

Gu, J ;

Gong, EC ;

Zhang, B ;

Zheng, J ;

Gao, ZF ;

Zhong, YF ;

Zou, WZ ;

Zhan, J ;

Wang, SL ;

Xie, ZG ;

Zhuang, H ;

Wu, BQ ;

Zhong, HH ;

Shao, HQ ;

Fang, WG ;

Gao, DS ;

Pei, F ;

Li, XW ;

He, ZP ;

Xu, DZ ;

Shi, XY ;

Anderson, VM ;

Leong, ASY .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (03) :415-424

[7] Neurologic Features in Severe SARS-CoV-2 Infection [J].

Helms, Julie ;

Meziani, Ferhat .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (23) :2268-2270

[8] Neurological Complications during Treatment of Middle East Respiratory Syndrome [J].

Kim, Jee-Eun ;

Heo, Jae-Hyeok ;

Kim, Hye-Ok ;

Song, Sook-Hee ;

Park, Sang-Soon ;

Park, Tai-Hwan ;

Ahn, Jin-Young ;

Kim, Min-Ky ;

Choi, Jae-Phil .

JOURNAL OF CLINICAL NEUROLOGY, 2017, 13 (03) :227-233

[9] Infectious immunity in the central nervous system and brain function [J].

Klein, Robyn S. ;

Garber, Charise ;

Howard, Nicole .

NATURE IMMUNOLOGY, 2017, 18 (02) :132-141

[10] Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China [J].

Mao, Ling ;

Jin, Huijuan ;

Wang, Mengdie ;

Hu, Yu ;

Chen, Shengcai ;

He, Quanwei ;

Chang, Jiang ;

Hong, Candong ;

Zhou, Yifan ;

Wang, David ;

Miao, Xiaoping ;

Li, Yanan ;

Hu, Bo .

JAMA NEUROLOGY, 2020, 77 (06) :683-690

← 1 2 3 →