Incorporating chitosan (CS) and TPP into silk fibroin (SF) in fabricating spray-dried microparticles prolongs the release of a hydrophilic drug

被引:13
作者
Chung, Tze-Wen [1 ]
Chang, Chih-Hao [2 ,3 ,4 ,5 ]
Ho, Chia-Wei [1 ]
机构
[1] Natl Yunlin Univ Sci & Technol, Dept Chem & Mat Engn, Dou Liu 640, Yun Lin, Taiwan
[2] Natl Taiwan Univ, Inst Biomed Engn, Coll Engn, Taipei 10764, Taiwan
[3] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan
[4] Natl Taiwan Univ, Coll Med, Taipei 10018, Taiwan
[5] Natl Taiwan Univ Hosp, Dept Orthoped, Taipei 10018, Taiwan
关键词
Silk fibroin/chitosan; Drug delivery; Tri-polyphosphate anhydrous; Microparticles; Spray-drying; IN-VITRO; ENDOTHELIAL-CELLS; DELIVERY; MICROSPHERES; SCAFFOLDS; POLYMER; GROWTH; FILMS; VIVO;
D O I
10.1016/j.jtice.2010.11.003
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
In this investigation, drug delivery characteristics of incorporating CS and anhydrous tri-polyphosphate (TPP) into SF in fabricating microparticles by a spray-dried technique were examined. Among various formulas, SF/CS microparticles at 10/4.0 (weight ratio) had the highest positive zeta potential (23.0 +/- 3.60 mV (n = 3)) while SF ones showed a negative zeta potential (-14.7 +/- 1.5 mV (n = 3)). The equilibrium swelling ratio of SF/CS (10/4.0) microparticles was 9.80 +/- 0.77 times of themselves in a dry state, which was higher than those of SF and SF/CS (10/4.0)-TPP (0.05%) ones (e.g., 5.50 +/- 0.58 and 7.43 +/- 1.43 times, respectively). The release period for a model hydrophilic drug, tetracycline.Hcl (Tc), from SF was two days which prolonged to four and ten days for SF/CS (10/4.0) and SF/CS (10/4.0)-TPP (0.05%) microparticles, respectively. Through this investigation, new microparticulate SF/CS (10/4.0)-TPP (0.05%) is highly promising for drug delivery applications. (C) 2010 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:592 / 597
页数:6
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