Role of Granulosa Cells in the Aging Ovarian Landscape: A Focus on Mitochondrial and Metabolic Function

被引：35

作者：

Alberico, Hannah C. ^{[1
]}

Woods, Dori C. ^{[1
]}

机构：

[1] Northeastern Univ, Dept Biol, Boston, MA 02115 USA

来源：

FRONTIERS IN PHYSIOLOGY | 2022年 / 12卷

基金：

美国国家科学基金会;

关键词：

granulosa cells; ovarian aging; mitochondria; reproduction; oocytes; ACUTE REGULATORY PROTEIN; MOUSE OOCYTE MATURATION; AGE-RELATED-CHANGES; DNA COPY NUMBER; CUMULUS CELLS; FOLLICLE CELLS; GAP-JUNCTIONS; MATERNAL AGE; BIDIRECTIONAL COMMUNICATION; CHROMOSOME-ABNORMALITIES;

D O I：

10.3389/fphys.2021.800739

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mitochondria are at the intersection of aging and fertility, with research efforts centered largely on the role that these specialized organelles play in the relatively rapid decline in oocyte quality that occurs as females approach reproductive senescence. In addition to various roles in oocyte maturation, fertilization, and embryogenesis, mitochondria are critical to granulosa cell function. Herein, we provide a review of the literature pertaining to the role of mitochondria in granulosa cell function, with emphasis on how mitochondrial aging in granulosa cells may impact reproduction in female mammals.

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