One-Pot Synthesis of 3-Methyl-2-arylimidazo[1,2-a]pyridines Using Calcium Carbide as an Alkyne Source

被引：32
|
作者：
Chen, Wei [1 ]
Li, Zheng [1 ]
机构：
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 01期
基金：
中国国家自然科学基金;
关键词：
CARBOXYLIC-ACIDS; ZOLPIDEM; 2-AMINOPYRIDINE; TOLERABILITY; DERIVATIVES; MANAGEMENT; OLPRINONE; KETONES;
D O I：
10.1021/acs.joc.1c01877
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the construction of 3-methyl-2-arylimidazo[1,2-a]pyridines from the reactions of calcium carbide, 2-aminopyridines, and aromatic aldehydes is described. The notable advantages for this strategy include the use of an inexpensive and concise solid alkyne source, cheap and readily available raw materials, wide-scope substrates, and a simple work-up procedure.
引用
收藏
页码：76 / 84
页数：9
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