Oxybutynin effects on Staphylococcus epidermidis biofilm production

被引:0
作者
Gedik, Abdullah
Ersay, Ahmet
Atmaca, Selahattin
Sener, Alper
机构
[1] Diyarbakir Hosp, Urol Clin, Dept Urol, Diyarbakir, Turkey
[2] Dicle Univ, Sch Med, Dept Urol, Diyarbakir, Turkey
[3] Canakkale Onsekiz Mart Univ, Med Coll Canakkale, Canakkale, Turkey
关键词
biofilm; oxybutynin; Staphylococcus epidermidis;
D O I
10.1097/01.smj.0000305885.23903.71
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Oxybutynin is a tertiary amine and has chemical similarities like prolamine sulfate. Protamine sulfate's effect on bacterial viability has been shown in some studies; however, there is scanty data regarding the effect of oxybutynin on bacterial viability. Accordingly, the aim of the present study was to investigate the effect of oxybutynin on bacterial viability. Methods: Twenty of Staphylococcus epidermidis (S. epidermidis) strains were isolated from patients who had catheter-associated urinary tract infection. These strains were exposed to 5 different concentrations of oxybutynin in tryptic soy broth (TSB) media (max: 5 mg/mL, min: 0.05 mg/mL). Quantitative growth patterns were measured by spectrophotometer. Under the same media conditions, biofilm production of individual strains was measured by Deighton's micromethod at the end of the 6-hour incubation period. Results: After the incubation period, weak and strong slime-producing bacteria groups were obtained and both groups' slime productions were extensively low at 5 mg/mL concentration of oxybutynin. Slime production of S. epidermidis was inversely correlated with oxybutynin concentrations. Conclusion: Although there was a dose-dependent reduction of biofilm production, there seemed to be no bactericidal effect of oxybutynin on S. epidermidis.
引用
收藏
页码:236 / 239
页数:4
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