Hemocompatibility of a hydrodynamic levitation centrifugal blood pump

被引:27
作者
Yamane, Takashi [1 ]
Maruyama, Osamu [1 ]
Nishida, Masahiro [1 ]
Kosaka, Ryo [1 ]
Sugiyama, Daisuke [2 ]
Miyamoto, Yusuke [2 ]
Kawamura, Hiroshi [2 ]
Kato, Takahisa [3 ]
Sano, Takeshi [4 ]
Okubo, Takeshi [4 ]
Sankai, Yoshiyuki [5 ]
Shigeta, Osamu [5 ]
Tsutsui, Tatsuo [5 ]
机构
[1] Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Tsukuba, Ibaraki 3058564, Japan
[2] Tokyo Univ Sci, Chiba, Japan
[3] Univ Tokyo, Bunkyo Ku, Tokyo 113, Japan
[4] Mitsubishi Heavy Ind Co Ltd, Takasago, Hyogo, Japan
[5] Univ Tsukuba, Tsukuba, Ibaraki, Japan
关键词
artificial heart; centrifugal pump; hydrodynamic bearing; thrombus;
D O I
10.1007/s10047-006-0370-z
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A noncontact type centrifugal pump without any complicated control or sensing modules has been developed as a long-term implantable artificial heart. Centrifugal pumps with impellers levitated by original hydrodynamic bearings were designed and have been modified through numerical analyses and in vitro tests. The hemolysis level was reduced by changing the pressure distribution around the impeller and subsequently expanding the bearing gap. Thrombus formation in the bearing was examined with in vitro thrombogenesis tests and was reduced by changing the groove shapes to increase the bearing-gap flow to 3% of the external flow. Unnecessary vortices around the vanes were also eliminated by changing the number of vanes from four to six.
引用
收藏
页码:71 / 76
页数:6
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