Hypothyroidism and Non-Alcoholic Fatty Liver Disease

被引：0

作者：

Hazam, Randa ^{[1
]}

Taha, Ahmed ^{[2
]}

Kimbugwe, John ^{[1
]}

Elzubeir, Nahla ^{[1
]}

Prakash, Sameer ^{[1
]}

Mubeen, Faiza ^{[1
]}

Khandheria, Bharat ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Internal Med, Hlth Sci Ctr, 1400 Coulter St,Suite 2700, Amarillo, TX 79106 USA

[2] Deaconess Hosp, Dept Internal Med, Evansville, IN USA

来源：

JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2020年 / 10卷 / 02期

关键词：

Liver cirrhosis; Non-alcoholic fatty liver disease; Hypothyroidism; GROWTH-FACTOR; 21; THYROID-FUNCTION; FGF21; LEVELS; PREVALENCE; RISK;

D O I：

10.14740/jem644

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Data supporting an association between primary hypothyroidism and non-alcoholic fatty liver disease (NAFLD) is lacking. Thyroid hormones are totally involved in the regulation of body weight, lipid metabolism, and insulin resistance. Therefore, thyroid hormones may have a role in the pathogenesis of NAFLD and nonalcoholic steatohepatitis (NASH). The results of studies investigating the association between NAFLD and thyroid dysfunction have been inconsistent; many have provided data supporting the association, while a few others have refuted it. This report presents the case of a 56-year-old obese Hispanic man who was diagnosed with liver cirrhosis secondary to NAFLD and presented 3 months later with severe hypothyroidism.

引用

页码：45 / 48

页数：4

共 22 条

[1] Thyroid Hormone Regulates Hepatic Expression of Fibroblast Growth Factor 21 in a PPARα-dependent Manner [J].

Adams, Andrew C. ;

Astapova, Inna ;

Fisher, Ffolliott M. ;

Badman, Michael K. ;

Kurgansky, Katherine E. ;

Flier, Jeffrey S. ;

Hollenberg, Anthony N. ;

Maratos-Flier, Eleftheria .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (19) :14078-14082

[2]

[Anonymous], 2013, INT J ENDOCRINOL, DOI DOI 10.1155/2013/381014

[3] Thyroid Function and the Risk of Nonalcoholic Fatty Liver Disease: The Rotterdam Study [J].

Bano, Arjola ;

Chaker, Layal ;

Plompen, Elisabeth P. C. ;

Hofman, Albert ;

Dehghan, Abbas ;

Franco, Oscar H. ;

Janssen, Harry L. A. ;

Murad, Sarwa Darwish ;

Peeters, Robin P. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (08) :3204-3211

[4] Metabolic syndrome prevalence in subclinic and overt hypothyroid patients and the relation among metabolic syndrome parameters [J].

Erdogan, M. ;

Canataroglu, A. ;

Ganidagli, S. ;

Kulaksizoglu, M. .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2011, 34 (07) :488-492

[5] Association of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis [J].

Guo, Zeqi ;

Li, Miaomiao ;

Han, Bing ;

Qi, Xingshun .

DIGESTIVE AND LIVER DISEASE, 2018, 50 (11) :1153-1162

[6] Nonalcoholic Fatty Liver Disease Is Not Associated with Thyroid Hormone Levels and Hypothyroidism: A Systematic Review and Meta-Analysis [J].

Jaruvongvanich, Veeravich ;

Sanguankeo, Anawin ;

Upala, Sikarin .

EUROPEAN THYROID JOURNAL, 2017, 6 (04) :208-215

[7] Thyroid dysfunction and hepatic steatosis in overweight children and adolescents [J].

Kaltenbach, T. E. -M. ;

Graeter, T. ;

Oeztuerk, S. ;

Holzner, D. ;

Kratzer, W. ;

Wabitsch, M. ;

Denzer, C. .

PEDIATRIC OBESITY, 2017, 12 (01) :67-74

[8] Subclinical Hypothyroidism and Low-Normal Thyroid Function Are Associated With Nonalcoholic Steatohepatitis and Fibrosis [J].

Kim, Donghee ;

Kim, Won ;

Joo, Sae Kyung ;

Bae, Jeong Mo ;

Kim, Jung Ho ;

Ahmed, Aijaz .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2018, 16 (01) :123-+

[9]

Lee Y, 2013, ENDOCR J, V60, P977

[10] Serum leptin levels in hypo- and hyperthyroidism [J].

Leonhardt, U ;

Ritzel, U ;

Schäfer, G ;

Becker, W ;

Ramadori, G .

JOURNAL OF ENDOCRINOLOGY, 1998, 157 (01) :75-79

← 1 2 3 →