Fellowship of the rings: the replication of kinetoplast DNA

被引：181

作者：

Liu, BY ^{[1
]}

Liu, YN ^{[1
]}

Motyka, SA ^{[1
]}

Agbo, EEC ^{[1
]}

Englund, PT ^{[1
]}

机构：

[1] Johns Hopkins Med Sch, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

TRENDS IN PARASITOLOGY | 2005年 / 21卷 / 08期

关键词：

D O I：

10.1016/j.pt.2005.06.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Kinetoplastid protozoa such as trypanosomes and Leishmania are important because they cause human disease. These parasites are named after one of their most unusual features, a mitochondrial DNA known as kinetoplast DNA (kDNA). Unlike all other DNA in nature, kDNA comprises a giant network of interlocked DNA rings with a topology resembling that of medieval chain mail. The replication of the kDNA network is more complex than previously thought, and the discovery of new proteins involved in this process is currently the best approach for illuminating the replication mechanism.

引用

页码：363 / 369

页数：7

共 58 条

[11] The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library [J].

Drew, ME ;

Morris, JC ;

Wang, ZF ;

Wells, L ;

Sanchez, M ;

Landfear, SM ;

Englund, PT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (47) :46596-46600

[12] Intramitochondrial location and dynamics of Crithidia fasciculata kinetoplast minicircle replication intermediates [J].

Drew, ME ;

Englund, PT .

JOURNAL OF CELL BIOLOGY, 2001, 153 (04) :735-743

[13] The Crithidia fasciculata RNH1 gene encodes both nuclear and mitochondrial isoforms of RNase H [J].

Engel, ML ;

Hines, JC ;

Ray, DS .

NUCLEIC ACIDS RESEARCH, 2001, 29 (03) :725-731

[14] The kinetoplast structure-specific endonuclease I is related to the 5′ exo/endonuclease domain of bacterial DNA polymerase I and colocalizes with the kinetoplast topoisomerase II and DNA polymerase β during replication [J].

Engel, ML ;

Ray, DS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8455-8460

[15]

ENGLUND PT, 1979, J BIOL CHEM, V254, P4895

[16] INSITU HYBRIDIZATION TO THE CRITHIDIA-FASCICULATA KINETOPLAST REVEALS 2 ANTIPODAL SITES INVOLVED IN KINETOPLAST DNA-REPLICATION [J].

FERGUSON, M ;

TORRI, AF ;

WARD, DC ;

ENGLUND, PT .

CELL, 1992, 70 (04) :621-629

[17] KINETOPLAST DNA-REPLICATION - MECHANISTIC DIFFERENCES BETWEEN TRYPANOSOMA-BRUCEI AND CRITHIDIA-FASCICULATA [J].

FERGUSON, ML ;

TORRI, AF ;

PEREZMORGA, D ;

WARD, DC ;

ENGLUND, PT .

JOURNAL OF CELL BIOLOGY, 1994, 126 (03) :631-639

[18]

Guilbride DL, 1998, J CELL SCI, V111, P675

[19] REPLICATION OF KINETOPLAST DNA MAXICIRCLES [J].

HAJDUK, SL ;

KLEIN, VA ;

ENGLUND, PT .

CELL, 1984, 36 (02) :483-492

[20] THE SEGREGATION OF KINETOPLAST DNA NETWORKS IN TRYPANOSOMA-BRUCEI [J].

HOEIJMAKERS, JHJ ;

WEIJERS, PJ .

PLASMID, 1980, 4 (01) :97-116

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