Functional Neuroimaging in Obsessive-Compulsive Disorder

被引：154

作者：

Del Casale, A. ^{[1
,2
]}

Kotzalidis, G. D. ^{[1
]}

Rapinesi, C. ^{[1
]}

Serata, D. ^{[1
]}

Ambrosi, E. ^{[1
]}

Simonetti, A. ^{[1
]}

Pompili, M. ^{[1
,3
]}

Ferracuti, S. ^{[1
]}

Tatarelli, R. ^{[1
]}

Girardi, P. ^{[1
]}

机构：

[1] Sapienza Univ, NESMOS Neurosci Mental Hlth & Sensory Funct Dept, Sch Med & Psychol, IT-00189 Rome, Italy

[2] Sapienza Univ, NESMOS Neurosci Mental Hlth & Sensory Funct Dept, Sch Med & Psychol, St Andrea Hosp, IT-00189 Rome, Italy

[3] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA 02178 USA

来源：

NEUROPSYCHOBIOLOGY | 2011年 / 64卷 / 02期

关键词：

Obsessive-compulsive disorder; Functional neuroimaging; Striatum; Orbitofrontal cortex; Cognitive functions; CEREBRAL-BLOOD-FLOW; GLUCOSE METABOLIC-RATES; FRONTAL-LOBE ACTIVATION; TOWER-OF-LONDON; POSITRON-EMISSION-TOMOGRAPHY; SPATIAL WORKING-MEMORY; MAGNETIC-RESONANCE; SYMPTOM PROVOCATION; PREFRONTAL CORTEX; BRAIN ACTIVATION;

D O I：

10.1159/000325223

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background and Aim: Obsessive-compulsive disorder (OCD) is a severe, highly prevalent and chronically disabling psychiatric disorder that usually emerges during childhood or adolescence. This paper aims to review the literature on functional neuroimaging in OCD, analysing the reported dysfunctional connectivity in the corticostriatothalamocortical circuitry. Method: This study included papers published in peer-reviewed journals dealing with functional imaging in OCD. Results: Striatal dysfunction, mainly of the caudate nucleus, leads to inefficient thalamic gating, resulting in hyperactivity within the orbitofrontal cortex (intrusive thoughts) and the anterior cingulate cortex (non-specific anxiety). Compulsions consist of ritualistic behaviours performed to recruit the inefficient striatum and neutralise unwanted thoughts and anxiety. Functional neuroimaging findings are discussed against the background of specific cognitive impairments, mainly regarding visuospatial processing, executive functioning and motor speed. Cognitive deficits are partial and specific, matching imaging data. Conclusions: Several studies have targeted brain regions hypothesised to be involved in the pathogenesis of OCD, showing the existence of dysfunctional connectivity in the corticostriatothalamocortical circuitry. Improvements in spatial resolution of neuroimaging techniques may contribute to a better understanding of the neurocircuitry of OCD and other anxiety disorders. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：61 / 85

页数：25

共 185 条

[1] The selective breakdown of frontal functions in patients with obsessive-compulsive disorder and in patients with schizophrenia: A double dissociation experimental finding [J].