Prevalence of 16S rRNA methylase genes in Enterobacteriaceae isolates from a Greek University Hospital

被引：36

作者：

Galani, I. ^{[1
]}

Souli, M. ^{[1
]}

Panagea, T. ^{[1
]}

Poulakou, G. ^{[1
]}

Kanellakopoulou, K. ^{[1
]}

Giamarellou, H. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Mol Biol Sect, Dept Internal Med 4,Infect Dis Lab, Chaidari, Greece

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2012年 / 18卷 / 03期

关键词：

armA; Klebsiella pneumoniae; Proteus mirabilis; rmtB; rmtC; RESISTANCE; SPECTRUM; ARMA;

D O I：

10.1111/j.1469-0691.2011.03738.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

16S ribosomal RNA methylase-mediated high-level resistance to 4-,6-aminoglycosides has been reported in clinical isolates of gram-negative bacilli from several countries. Three of 1534 (0.2%) isolates of Klebsiella pneumoniae and three of 734 (0.4%) Proteus mirabilis isolates from a university hospital in Athens, Greece, were positive for rmtB and highly resistant to all aminoglycosides tested (MICs =256 mg/L). Two of the K. pneumoniae rmtB-bearing isolates, were KPC-2 and OXA-10 producers and the third was a DHA-1 producer. One of the P. mirabilis isolates was a VIM-1 and OXA-10 producer and one was an OXA-10 producer. All rmtB-harbouring isolates were clonally unrelated. None of the E. coli (n = 1398) and Enterobacter spp. (n = 414) isolates were positive for armA, rmtA, rmtB, rmtC or rmtD.

引用

页码：E52 / E54

页数：3

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