Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England

被引:32
作者
Campbell, Helen E. [1 ]
Stokes, Elizabeth A. [1 ]
Bargo, Danielle N. [2 ]
Curry, Nicola [3 ]
Lecky, Fiona E. [4 ]
Edwards, Antoinette [4 ]
Woodford, Maralyn [4 ]
Seeney, Frances [5 ]
Eaglestone, Simon [6 ]
Brohi, Karim [6 ]
Gray, Alastair M. [1 ]
Stanworth, Simon J. [7 ,8 ]
机构
[1] Univ Oxford, Hlth Econ Res Ctr, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England
[2] Eli Lilly & Co Ltd, Basingstoke RG24 9NL, Hants, England
[3] Churchill Hosp, Oxford Univ Hosp NHS Trust, Oxford Haemophilia & Thrombosis Ctr, Oxford OX3 7LE, England
[4] Salford Royal NHS Fdn Trust, Trauma Audit & Res Network, Salford M6 8HD, Lancs, England
[5] NHS Blood & Transplant Clin Trials Unit, Bristol BS34 8RR, Avon, England
[6] Barts & London Queen Marys Sch Med & Dent, Blizard Inst, London E1 2AT, England
[7] John Radcliffe Hosp, NHS Blood & Transplant, Oxford OX3 9BQ, England
[8] John Radcliffe Hosp, Oxford Univ Hosp NHS Trust, Oxford OX3 9BQ, England
来源
CRITICAL CARE | 2015年 / 19卷
关键词
MASSIVE TRANSFUSION; ECONOMIC-EVALUATION; BLUNT TRAUMA; WALES; BLOOD; COAGULOPATHY; MANAGEMENT; OUTCOMES; TRIAL;
D O I
10.1186/s13054-015-0987-5
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Introduction: Severely bleeding trauma patients are a small proportion of the major trauma population but account for 40 % of all trauma deaths. Healthcare resource use and costs are likely to be substantial but have not been fully quantified. Knowledge of costs is essential for developing targeted cost reduction strategies, informing health policy, and ensuring the cost-effectiveness of interventions. Methods: In collaboration with the Trauma Audit Research Network (TARN) detailed patient-level data on in-hospital resource use, extended care at hospital discharge, and readmissions up to 12 months post-injury were collected on 441 consecutive adult major trauma patients with severe bleeding presenting at 22 hospitals (21 in England and one in Wales). Resource use data were costed using national unit costs and mean costs estimated for the cohort and for clinically relevant subgroups. Using nationally available data on trauma presentations in England, patient-level cost estimates were up-scaled to a national level. Results: The mean (95 % confidence interval) total cost of initial hospital inpatient care was 19,770 pound (18,177 pound to 21,364) pound per patient, of which 62 % was attributable to ventilation, intensive care, and ward stays, 16 % to surgery, and 12 % to blood component transfusion. Nursing home and rehabilitation unit care and re-admissions to hospital increased the cost to 20,591 pound (18,924 pound to 22,257) pound. Costs were significantly higher for more severely injured trauma patients (Injury Severity Score >= 15) and those with blunt injuries. Cost estimates for England were 148,300,000 pound, with over a third of this cost attributable to patients aged 65 years and over. Conclusions: Severely bleeding major trauma patients are a high cost subgroup of all major trauma patients, and the cost burden is projected to rise further as a consequence of an aging population and as evidence continues to emerge on the benefits of early and simultaneous administration of blood products in pre-specified ratios. The findings from this study provide a previously unreported baseline from which the potential impact of changes to service provision and/ or treatment practice can begin to be evaluated. Further studies are still required to determine the full costs of post-discharge care requirements, which are also likely to be substantial.
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