Synthesis and biological evaluation of some novel thiazole substituted benzotriazole derivatives

被引：61

作者：

Gaikwad, Nitin D. ^{[2
]}

Patil, Sachin V. ^{[1
]}

Bobade, Vivek D. ^{[1
]}

机构：

[1] HPT Arts & RYK Sci Coll, Dept Chem, Nasik 422005, India

[2] KTHM Coll, Dept Chem, Nasik 422005, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 10期

关键词：

Thiazole; Benzotriazole; Hydrazone; MIC; MBC; MFC; ANTIMICROBIAL ACTIVITY; ANTIFUNGAL ACTIVITY; NATURAL-PRODUCTS; CYTOCHROME-P450; ANTICONVULSANT; ANALOGS; HYDRAZONES; ACIDS;

D O I：

10.1016/j.bmcl.2012.03.094

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel hybrid molecules 4a-y containing thiazole and benzotriazole templates were designed and synthesized. The structures of the synthesized compounds were elucidated by IR, H-1 NMR, C-13 NMR and mass spectral data. All the synthesized compounds were tested for their antimicrobial activity (zone of inhibition) against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. After that minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs) and minimum fungicidal concentrations (MFCs) of all the synthesized compounds were determined. The investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good microbial inhibitions. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3449 / 3454

页数：6

共 61 条

[1] Synthesis and antiviral evaluation of some sugar arylglycinoylhydrazones and their oxadiazoline derivatives [J].