Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery

被引:32
|
作者
Li, Yirui [2 ]
Champion, Julie A. [1 ,2 ]
机构
[1] Georgia Inst Technol, Sch Chem & Biomol Engn, 950 Atlantic Dr NW, Atlanta, GA 30332 USA
[2] Georgia Inst Technol, Bioengn Program, Atlanta, GA USA
基金
美国国家科学基金会;
关键词
INVERSE TEMPERATURE TRANSITION; ARTIFICIAL VIRAL CAPSIDS; SPIDER SILK SPHERES; COILED-COILS; CELLULAR UPTAKE; PEPTIDE; NANOPARTICLE; POLYMERS; CAGES; DNA;
D O I
10.1016/j.addr.2022.114462
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Self-assembling proteins are valuable building blocks for constructing drug nanocarriers due to their self-assembly behavior, monodispersity, biocompatibility, and biodegradability. Genetic and chemical modifications allow for modular design of protein nanocarriers with effective drug encapsulation, targetability, stimuli responsiveness, and in vivo half-life. Protein nanocarriers have been developed to deliver various therapeutic molecules including small molecules, proteins, and nucleic acids with proven in vitro and in vivo efficacy. This article reviews recent advances in protein nanocarriers that are not derived from natural protein nanostructures, such as protein cages or virus like particles. The protein nanocarriers described here are self-assembled from rationally or de novo designed recombinant proteins, as well as recombinant proteins complexed with other biomolecules, presenting properties that are unique from those of natural protein carriers. Design, functionalization, and therapeutic application of protein nanocarriers will be discussed. (C) 2022 Elsevier B.V. All rights reserved.
引用
收藏
页数:18
相关论文
共 50 条
  • [31] Redox Sensitive Self-Assembling Dipeptide for Sustained Intracellular Drug Delivery
    Dhawan, Sameer
    Ghosh, Sukanya
    Ravinder, R.
    Bais, Sachendra S.
    Basak, Soumen
    Krishnan, N. M. Anoop
    Agarwal, Manish
    Banerjee, Manidipa
    Haridas, V.
    BIOCONJUGATE CHEMISTRY, 2019, 30 (09) : 2458 - 2468
  • [32] New self-assembling polyaspartylhydrazide copolymer micelles for anticancer drug delivery
    Licciardi, Mariano
    Cavallaro, Gennara
    Di Stefano, Mauro
    Pitarresi, Giovanna
    Fiorica, Calogero
    Giammona, Gaetano
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 396 (1-2) : 219 - 228
  • [33] Predicting the Complex Phase Behavior of Self-Assembling Drug Delivery Nanoparticles
    Le, Tu C.
    Mulet, Xavier
    Burden, Frank R.
    Winkler, David A.
    MOLECULAR PHARMACEUTICS, 2013, 10 (04) : 1368 - 1377
  • [34] Lipid-like Self-Assembling Peptide Nanovesicles for Drug Delivery
    Fatouros, Dimitrios G.
    Lamprou, Dimitrios A.
    Urquhart, Andrew J.
    Yannopoulos, Spyros N.
    Vizirianakis, Ioannis S.
    Zhang, Shuguang
    Koutsopoulos, Sotirios
    ACS APPLIED MATERIALS & INTERFACES, 2014, 6 (11) : 8184 - 8189
  • [35] Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery
    Peng, Fei
    Zhang, Wensheng
    Qiu, Feng
    CURRENT MEDICINAL CHEMISTRY, 2020, 27 (29) : 4855 - 4881
  • [36] Self-Assembling Peptide Nanofibrous Hydrogel as a Versatile Drug Delivery Platform
    Yu, Zhiqiang
    Xu, Quan
    Dong, Chenbo
    Lee, Su Seong
    Gao, Liqian
    Li, Yiwen
    D'Ortenzio, Mathew
    Wu, Jun
    CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (29) : 4342 - 4354
  • [37] Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery
    Skilling, Katherine J.
    Stocks, Michael J.
    Kellam, Barrie
    Ashford, Marianne
    Bradshaw, Tracey D.
    Burroughs, Laurence
    Marlow, Maria
    CHEMMEDCHEM, 2018, 13 (11) : 1098 - 1101
  • [38] Intracellular Delivery of Poorly Soluble Polyphenols: Elucidating the Interplay of Self-Assembling Nanocarriers and Human Chondrocytes
    Kann, Birthe
    Spengler, Christian
    Coradini, Karine
    Rigo, Lucas A.
    Bennink, Martin L.
    Jacobs, Karin
    Offerhaus, Herman L.
    Beck, Ruy C. R.
    Windbergs, Maike
    ANALYTICAL CHEMISTRY, 2016, 88 (14) : 7014 - 7022
  • [39] Molecular design and synthesis of self-assembling camptothecin drug amphiphiles
    Cheetham, Andrew G.
    Lin, Yi-an
    Lin, Ran
    Cui, Honggang
    ACTA PHARMACOLOGICA SINICA, 2017, 38 (06) : 874 - 884
  • [40] Molecular design and synthesis of self-assembling camptothecin drug amphiphiles
    Andrew G Cheetham
    Yi-an Lin
    Ran Lin
    Honggang Cui
    Acta Pharmacologica Sinica, 2017, 38 : 874 - 884