Neonatal soft tissue sarcomas

被引：49

作者：

Ferrari, Andrea ^{[1
]}

Orbach, Daniel ^{[2
]}

Sultan, Iyad ^{[3
]}

Casanova, Michela ^{[1
]}

Bisogno, Gianni ^{[4
]}

机构：

[1] Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, I-20133 Milan, MI, Italy

[2] Inst Curie, Dept Pediat, Paris, France

[3] King Hussein Canc Ctr, Dept Pediat Oncol, Amman, Jordan

[4] Univ Padua, Pediat Hematol & Oncol Div, Padua, Italy

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2012年 / 17卷 / 04期

关键词：

Infantile fibrosarcoma; Infants; Neonatal; Rhabdomyosarcoma; Soft tissue sarcomas; Vascular tumors; HEPATIC EPITHELIOID HEMANGIOENDOTHELIOMA; CONGENITAL-INFANTILE FIBROSARCOMA; RHABDOID TUMORS; PEDIATRIC-ONCOLOGY; INTERNATIONAL-SOCIETY; MESENCHYMAL TUMOR; 1ST YEAR; RHABDOMYOSARCOMA; AGE; HEMANGIOMAS;

D O I：

10.1016/j.siny.2012.05.003

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Soft tissue tumors in very young children pose diagnostic and therapeutic challenges. Vascular tumors are the most prevalent soft tissue neoplasms in the neonatal period. They are generally benign tumors, but may exhibit aggressive behaviour and cause life-threatening complications. Fibroblastic tumors of intermediate prognosis, more prevalent in very young children (especially infantile fibrosarcoma), are locally aggressive. Since metastases are unusual in this group of tumors, complete surgical resection is generally curative. However, these tumors often present a therapeutic challenge because of the location which makes complete surgical resection difficult. Among the malignant soft tissue tumors, rhabdomyosarcoma is most frequent. It is an aggressive high-grade tumor, with local invasiveness and a propensity to metastasize. These tumors respond to chemotherapy and radiotherapy. Neonates with rhabdomyosarcoma seem to have a worse prognosis than in older age groups. This may be a result of inappropriate dosing of chemotherapeutic agents and decreased use of radiation therapy among other factors. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：231 / 238

页数：8