Serum urate, metabolic syndrome, and cardiovascular risk factors.: A population-based study

被引：27

作者：

Puig, J. G. ^{[1
]}

Martinez, M. A. ^{[1
]}

Mora, M. ^{[1
]}

Fraile, J. M. ^{[1
]}

Montoya, F. ^{[1
]}

Torres, R. J. ^{[1
]}

机构：

[1] Hosp Univ La Paz, Med Serv, Interna Hosp Gen, Div Internal Med, Madrid 28046, Spain

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2008年 / 27卷 / 6-7期

关键词：

serum urate; hyperuricemia; metabolic syndrome; CRP; cardiovascular risk factors;

D O I：

10.1080/15257770802138582

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We studied the associations between serum urate levels (determined in 503 subjects from a population of 1,344 subjects living in northern Madrid) and both the metabolic syndrome (MS) (defined by the Adult Treatment Panel III criteria) and C-reactive protein (CRP, determined in 382 subjects). MS was diagnosed in 25% (95%CI, 21-28%) and was associated with hyperuricemia (p<0.001). There was a graded increase in serum urate levels with increasing number of MS components. Urate concentrations significantly correlated with waist circumference (r=0,455, p<0.01). Serum urate was not independently associated with CRP levels. This study shows that serum urate levels are associated with the presence of MS and each of its features.

引用

页码：620 / 623

页数：4

共 5 条

[1] Prevalence of the metabolic syndrome in individuals with hyperuricemia [J].

Choi, Hyon K. ;

Ford, Earl S. .

AMERICAN JOURNAL OF MEDICINE, 2007, 120 (05) :442-447

[2] Associations of serum uric acid with markers of inflammation, metabolic syndrome, and subclinical coronary atherosclerosis [J].

Coutinho, Thais de A. ;

Turner, Stephen T. ;

Peyser, Patricia A. ;

Bielak, Lawrence F. ;

Sheedy, Patrick F., II ;

Kullo, Iftikhar J. .

AMERICAN JOURNAL OF HYPERTENSION, 2007, 20 (01) :83-89

[3] Definition of metabolic syndrome - Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition [J].

Grundy, SM ;

Brewer, HB ;

Cleeman, JI ;

Smith, SC ;

Lenfant, C .

CIRCULATION, 2004, 109 (03) :433-438

[4] Serum uric acid is a determinant of metabolic syndrome in a population-based study [J].

Onat, Altan ;

Uyarel, Huseyin ;

Hergenc, Gulay ;

Karabulut, Ahmet ;

Albayrak, Sinan ;

Sari, Ibrahim ;

Yazici, Mehmet ;

Keles, Ibrahim .

AMERICAN JOURNAL OF HYPERTENSION, 2006, 19 (10) :1055-1062

[5] Relations of hyperuricemia with the various components of the Insulin Resistance Syndrome in young black and white adults: The CARDIA study [J].

Rathmann, W ;

Funkhouser, E ;

Dyer, AR ;

Roseman, JM .

ANNALS OF EPIDEMIOLOGY, 1998, 8 (04) :250-261

← 1 →