The effects of long-term aging at 1070 degrees C for periods of 100 h to 1500 h on microstructure of Ni3Al-base single-crystal alloy IC6SX were examined by SEM, EDX and TEM. Results show that alloy IC6SX undergoes following microstructure changes during long-term aging: a large number of rod-like Y-NiMo phases and carbides precipitate, and more of them appear in the interdendritic areas than in the dendritic arms; gamma-phase aggregate and coarsen, and no longer show a continuous network-like distribution; adjacent gamma' phases grow bigger and become connected with each other; some larger sized gamma' phases are discovered in the dendritic arms; after aging for 300 h, gamma phases amid a row of adjacent gamma' phases dissolve to form a gamma' band, and during further aging, gamma phases beside the gamma' band grow wider and finally occupy the gamma' band, where a gamma band is formed; a small portion of Y-NiMo phases are found to re-dissolve to form gamma phases after aging for 1500 h.