Urinary Tract Infections and Their Prevention

被引:12
作者
Gonzalez-Chamorro, F. [1 ]
Palacios, R. [2 ]
Alcover, J. [2 ]
Campos, J. [2 ]
Borrego, F. [3 ]
Damaso, D. [4 ]
机构
[1] Hosp San Rafael, Serv Urol, Madrid, Spain
[2] Diater Lab, Madrid, Spain
[3] Grp Ferrer, Murcia, Spain
[4] Univ Autonoma Madrid, Fac Med, Dept Med Prevent Salud Publ & Microbiol, Madrid, Spain
来源
ACTAS UROLOGICAS ESPANOLAS | 2012年 / 36卷 / 01期
关键词
Urinary infection; Adherence; Fimbriae; Biofilms; Vaccines; ESCHERICHIA-COLI STRAINS; ASYMPTOMATIC BACTERIURIA; IN-VITRO; PROPHYLAXIS;
D O I
10.1016/j.acuro.2011.05.002
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Context: This article reviews diverse aspects of the prevention of urinary tract infections, including confirmation of the diagnosis, application of hygiene and dietary measures, antibacterial prophylaxis (preferably consisting of a single nocturnal oral dose per day of an antibiotic or drug with high urinary excretion and good tolerance), and administration of vaccines made with Escherichia coli and other Gram-negative bacilli, consisting of immunostimulating fractions of E. coli strains or E. coli type-1 fimbriae administered through the parenteral or oral route. Objective: We aimed to review the new preventive measures against urinary tract infections. Acquisition and synthesis of evidence: We reviewed various microbiological aspects, as well as the physiopathology and virulence factors of uropathogenic E. coli strains expressing type-1 and P fimbriae. The association between blood groups and urinary tract infections in blood group antigen-secretors and nonsecretors was analyzed. Conclusions: New preventive measures against urinary tract infection consist of the use of phenol-inactivated vaccines administered via the mucosal route, inhibitors of bacterial adherence and biofilm formation and cyclic adenosine monophosphate stimulators, especially in women aged between puberty and menopause, who show the highest incidence of these infections. (C) 2011 AEU. Published by Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码:48 / 53
页数:6
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